Renoprotective Effect of the Shen-Yan-Fang-Shuai Formula by Inhibiting TNF-α/NF-κB Signaling Pathway in Diabetic Rats

Figure 1

SYFSF attenuated renal injury in DKD rats. (a) Blood glucose was significantly increased after uninephrectomy, STZ-injection, and high-fat-diet induction. The glucose level in the SYFSF group was lower compared with that in the DKD and irbesartan groups. (b) Compared with the normal rats, the diabetic rats developed significant emaciation. (c) The 24-hour urinary protein in the DKD group increased markedly which was significantly suppressed by SYFSF treatment. (d) The levels of serum creatinine between the SYFSF group and the irbesartan group had statistical significance. (e, f) Serum cholesterol and triglyceride levels obviously increased in the diabetic groups, and SYFSF obviously decreased the levels of cholesterol and triglyceride. DKD + S represents the DKD rats treated with SYFSF. DKD + I represents the DKD rats treated with irbesartan. , , and .

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