Renoprotective Effect of the Shen-Yan-Fang-Shuai Formula by Inhibiting TNF-α/NF-κB Signaling Pathway in Diabetic Rats

Figure 3

SYFSF serum inhibited renal inflammation in DKD rats. (a) Immunohistochemical staining of MCP-1, TNF-α, and NF-κBp65 is shown. (b, c) The expression of MCP-1, TNF-α, and NF-κBp65 was scored. SYFSF inhibited the expression of MCP-1 and TNF-α. (d) There was no significant difference in NF-κBp65 expression. (e, f) The expression of phosphorylated NF-κBp65 was obviously increased in the DKD group in western blot. SYFSF and irbesartan had almost similar effects on the inhibition of NF-κBp65 phosphorylation. DKD + S represents the DKD rats treated with SYFSF. DKD + I represents the DKD rats treated with irbesartan. , , and .

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