Effectiveness of Vildagliptin in Clinical Practice: Pooled Analysis of Three Korean Observational Studies (the VICTORY Study)

Table 1

Baseline patient characteristics according to HbA1c levels at 24 weeks.

	HbA1c ≤ 7.0% at 24 weeks; ()	HbA1c > 7.0% at 24 weeks; ()	Total; ()	value
Gender, n (%)
Male	695 (56.5)	449 (52.4)	1144 (54.8)	0.0633^a
Age (years)
Mean ± SD	56.8 ± 11.0	57.3 ± 11.7	57.0 ± 11.3	0.2517^b
Weight (kg)
N	1092	778	1870
Mean ± SD	67.5 ± 11.0	66.3 ± 10.9	67 ± 11.0	0.0215^b
Baseline HbA1c, n (%)
<7.5%	650 (52.9)	118 (13.8)	768 (36.8)	<0.0001^a
≥7.5%	580 (47.2)	739 (86.2)	1319 (63.2)
Elderly group, n (%)
<65 years	926 (75.3)	611 (71.3)	1537 (73.7)	0.0418^b
≥65 years	304 (24.7)	246 (28.7)	550 (26.4)
Treatment center type, n (%)
Hospital	600 (48.8)	283 (33.0)	883 (42.3)	<0.0001^b
Clinic	630 (51.2)	574 (67.0)	1204 (57.7)
Concurrent disease, n (%)
Yes	700 (56.9)	449 (52.4)	1149 (55.1)	0.0412^b
No	530 (43.1)	408 (47.6)	938 (44.9)
Medical history, n (%)
Yes	153 (12.4)	83 (9.7)	236 (11.3)	0.0296^b
No	1036 (84.2)	756 (88.21)	1792 (85.9)
Concomitant medications (except for diabetes medications), n (%)
Yes	733 (59.6)	448 (52.3)	1181 (56.6)	0.0009^b
No	497 (40.4)	409 (47.7)	906 (43.4)
Duration of T2DM (years)
n	1067	785	1852
Mean ± SD	5.1 ± 5.3	7.7 ± 6.0	6.2 ± 5.8	<0.0001^a
Drug combination type, n (%)
Vildagliptin + metformin^c	895 (72.8)	720 (84.0)	1615 (77.4)	<0.0001^b
Vildagliptin/metformin FDC^d	299 (24.3)	124 (14.5)	423 (20.3)
Pharmacotherapy at baseline, n (%)
Second-line therapy	1181 (96.0)	775 (90.4)	1956 (93.7)	<0.0001^b
Third- or further-line therapy	43 (3.5)	76 (8.9)	119 (5.7)
∆HbA1c (%)
12 weeks
N	923	699	1622
Mean ± SD	−0.9 ± 1.1	−0.6 ± 1.2	−0.8 ± 1.2	<0.0001^b
24 weeks
N	1230	857	2087
Mean ± SD	−1.2 ± 1.2	−0.8 ± 1.3	−1.0 ± 1.3	<0.0001^b
∆FBG (mg/dL)
12 weeks
N	535	359	894
Mean ± SD	−30.9 ± 47.1	−24.2 ± 57.7	−28.2 ± 51.7	0.0673^b
24 weeks
N	663	406	1069
Mean ± SD	−32.6 ± 48.8	−23.0 ± 60.2	−29.0 ± 53.6	0.0068^b

SD: standard deviation; T2DM: type 2 diabetes mellitus; FDC: fixed drug combination; FBG: fasting blood glucose. ^aChi-square test. ^bt-test. ^cVildagliptin + metformin free drug combination. ^dVildagliptin/metformin fixed dose combination.