PGC1α Activators Mitigate Diabetic Tubulopathy by Improving Mitochondrial Dynamics and Quality Control

Figure 1

PGC1α and AMPK expression in human renal proximal tubular cells (RPTCs) under high-glucose conditions. (a) Representative confocal fluorescence images of PGC1α indicate that high-glucose conditions suppress PGC1α expression in human RPTCs. (b) Western blot analyses reveal downregulation of PGC1α and AMPK under high-glucose conditions ( compared with the 5 mM glucose condition, scale bar 10 μm).

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