Diosgenin, a Novel Aldose Reductase Inhibitor, Attenuates the Galactosemic Cataract in Rats

<div>Effects of diosgenin on rat galactosemic cataract in vivo. (a) Effects of diosgenin on lens opacification evaluated using a slit lamp. (b) Effects of diosgenin on the ratio of lens weight to body weight, which represents the severity of lens osmotic expansion. (c) Effects of diosgenin on lens AR activity of galactosemic rats. (d) Effects of diosgenin on lens galactitol level of galactosemic rats. (e) Effects of diosgenin on lens AR mRNA expression of galactosemic rats. 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DG-100 and DG-200 mean diosgenin were given orally (100 and 200 mg/kg); DG-0.1% represents the rats who directly drank 0.1% diosgenin solution.</div>

Journal of Diabetes Research

fig3

Figure 3

Figure 3: Diosgenin, a Novel Aldose Reductase Inhibitor, Attenuates the Galactosemic Cataract in Rats 