Reduced Histone H3 Lysine 9 Methylation Contributes to the Pathogenesis of Latent Autoimmune Diabetes in Adults via Regulation of SUV39H2 and KDM4C

Figure 2

Reduced H3 lysine 9 methylation level in LADA patients. (a) Global H3 lysine 4 and H3 lysine 9 methylation level in CD4⁺ T lymphocytes from 26 LADA patients and 26 healthy controls, , LADA patients versus healthy controls. (b) Global H3 lysine 4 and H3 lysine 9 methylation level in CD4⁺ T lymphocytes from LADA patients, , LADA patients with low GADA titer () versus LADA patients with high GADA titer (). (c) Global H3 lysine 4 and H3 lysine 9 methylation level in in CD4⁺ T lymphocytes from LADA patients, , LADA patients with complications (LADAc, ) versus LADA patients without complications (LADAnc, ).

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