db/db Mice Exhibit Features of Human Type 2 Diabetes That Are Not Present in Weight-Matched C57BL/6J Mice Fed a Western Diet

Figure 1

Hyperglycemia develops in genetically driven, but not diet-induced obesity. Blood glucose (a) and body weight (c) in male C57BL/6J mice fed either control or Western diet for 20 weeks. Total weight gain (e) at the end of the 20-week feeding period. Blood glucose (b) and body weight (d) in male db/+ and db/db mice between 6 and 14 weeks of age. Total weight gain by 14 weeks of age (f). For body weight measurements (c and d), y-axes are set to the same scale for comparison between study groups. per group; means ± SEM; versus control; versus control by repeated measures ANOVA. CD: control diet; WD: Western diet.

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