The Constellation of Macrovascular Risk Factors in Early Onset T2DM: A Cross-Sectional Study in Xinjiang Province, China
Table 1
Clinical and biochemical characteristics of patients with early versus late onset of T2DM and control subjects matched for age and sex.
Variable
Early onset
Late onset
value
Control subjects
value#
Age (years)
39.5 ± 10.8
60.2 ± 8.3
<0.001
39.4 ± 7.1
0.103
Female gender
78 (35.6)
476 (45.)
0.005
182 (38.1)
0.556
Age of diabetes diagnosis (years)
34.3 ± 7.6
51.4 ± 7.2
<0.001
—
—
Duration of diabetes (years)
6.6 ± 8.0
8.8 ± 6.1
<0.001
—
—
Diabetic family history
138 (63.0)
499 (39.8)
<0.001
102 (21.3)
<0.001
BMI (kg/m2)
25.2 ± 4.9
26.1 ± 3.6
0.002
24.2 ± 2.8
0.009
Current cigarette smoking∗
99 (45.2)
381 (36.8)
0.012
213 (47.2)
0.680
Hypertension
112 (51.1)
582 (56.2)
0.330
153 (33.9)
<0.001
SBP (mmHg)
141.9 ± 25.1
137.4 ± 22.8
0.015
120.6 ± 18.0
<0.001
DBP (mmHg)
79.8 ± 14.7
77.1 ± 14.5
0.023
72.3 ± 12.7
<0.001
Fasting blood glucose (mmol/L)
10.3 ± 4.4
9.9 ± 4.6
0.680
4.9 ± 0.5
<0.001
2-h postprandial glucose (mmol/L)
15.7 ± 5.4
14.1 ± 5.2
0.535
5.7 ± 1.3
<0.001
HbA1c,% (mmol/mol)
9.1 ± 2.4 (76 ± 26)
8.3 ± 2.2 (67 ± 23)
0.039
5.2 ± 1.1 (33 ± 11)
<0.001
Required insulin therapy
160 (73.1)
608 (58.7)
<0.001
—
—
Triglyceride (mmol/L)
2.4 ± 1.6
2.2 ± 1.4
0.405
1.6 ± 0.9
<0.001
Total cholesterol (mmol/L)
4.1 ± 1.3
4.6 ± 1.5
0.952
3.7 ± 1.2
<0.001
HDL cholesterol (mmol/L)
1.1 ± 0.4
1.2 ± 0.4
0.397
1.2 ± 0.2
<0.001
LDL cholesterol (mmol/L)
2.6 ± 1.1
2.5 ± 1.0
0.500
2.1 ± 0.6
<0.001
Data are means ± SD or n (%). values were derived from chi-square test or Student’s t-test. BMI: body mass index; SBP/DBP: systolic/diastolic blood pressure; HbA1c: hemoglobin A1c; HDL cholesterol: high-density lipoprotein cholesterol; LDL cholesterol: low-density lipoprotein cholesterol. Current cigarette smoking, 1 or more cigarettes per day. #, early onset DM versus control subjects matched with age and sex.
