Advanced Glycation End Products Increase MDM2 Expression via Transcription Factor KLF5

Figure 6

Conclusion figure of our research in this paper. Advanced glycation end products promote the nucleus translocation of transcription factor KLF5, which directly bind to the transcriptional regulatory region of MDM2 and promote its expression. Overexpressed MDM2 directly binds and promotes cancer suppressor Rb and p53 degradation via the ubiquitination pathway.