Review Article
Diabetic Enteropathy: From Molecule to Mechanism-Based Treatment
Table 1
Accumulation of upstream glycolytic intermediates and their consequences.
| Glycolytic intermediate | Alternative pathway | Consequence |
| Glyceraldehyde-3-phosphate | (1) De novo synthesis of DAG | DAG activates protein kinase C resulting in altered intracellular phosphorylation levels | (2) Glycosylation pathways | Glycation of various intra- and extracellular proteins and lipids | Fructose-6-phosphate | (3) Hexosamine pathway | Glucose | (4) Polyol pathway | Leads to depletion of intracellular NADPH |
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leads to formation of advanced glycation end products (AGE). renders the neuron susceptible to oxidation. |