Comparative Biochemical and Histopathological Studies on the Efficacy of Metformin and Virgin Olive Oil against Streptozotocin-Induced Diabetes in Sprague-Dawley Rats

Figure 2

Photomicrographs of a section of the liver tissue of rats: (a—group 1: NC) almost normal hepatic structure (hepatocytes being radially arranged around the central vein and presence of von Kupffer cells lining the sinusoidal spaces) (200x magnification); (b—group 2: DC) numerous apoptotic dark-stained shrunken hepatocytes with small degenerated nuclei (400x magnification); (c—group 3: DM) nearly normal radially arranged hepatocytes around the central vein (it also shows that blood sinusoidal spaces and their von Kupffer cells are like those of the NC group) (400x magnification); (d—group 4: DO) almost normal hepatic structure with radially arranged hepatocytes around the central vein with the absence of any degenerated apoptotic cells (it also shows that hepatic sinusoidal spaces and von Kupffer cells are like those of the NC group) (400x magnification); (e—group 5: DOM) almost normal hepatic structure with radially arranged hepatocytes around the central vein (it also shows the presence of von Kupffer cells lining the sinusoidal spaces) (400x magnification); (f—group 6: DOP) almost normal hepatic structure with radially arranged hepatocytes around the central vein (it also shows active and healthy hepatocytes with active vesicular nuclei like that of the NC group) (400x magnification). All sections were stained with H and E stain and viewed with a light microscope.

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