Comparative Biochemical and Histopathological Studies on the Efficacy of Metformin and Virgin Olive Oil against Streptozotocin-Induced Diabetes in Sprague-Dawley Rats

Figure 3

Photomicrographs of a section of the kidney tissue of rats: (a—group 1: NC) normal renal corpuscles with normal glomerular capillaries and renal tubules (40x magnification); (b—group 2: DC) deformity of renal corpuscle with atrophy of glomerular capillaries and unstained degenerated cytoplasmic regions in the renal tubular epithelium and arterioles showing diffused muscular media thickening with perivascular edema, fibrosis, and minimal interstitium lymphocytic infiltrate (400x magnification); (c—group 3: DM) normal renal corpuscles and glomeruli (it also shows normal renal tubules) (400x magnification); (d—group 4: DO) marked protection from diabetic changes with renal corpuscle, glomeruli, and tubules looking like those of the NC group (200x magnification); (e—group 5: DOM) marked protection against diabetic changes (it also shows normal and healthy renal corpuscles, glomeruli, and tubules) (400x magnification); (f—group 6: DOP) marked protection against diabetic changes (it also shows normal and healthy renal corpuscles, glomeruli, and tubules like those of the NC group) (200x magnification). All sections were stained with H and E stain and viewed with a light microscope.

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