MicroRNA-22 Promotes Renal Tubulointerstitial Fibrosis by Targeting PTEN and Suppressing Autophagy in Diabetic Nephropathy

Figure 7

Principle signaling pathways involved in the effect of HG on autophagy and the expression of Col IV and α-SMA in NRK-52E cells. HG suppressed autophagy and in turn promoted Col IV and α-SMA expression via regulating PTEN/Akt/mTOR signaling pathway. By targeting PTEN, miR-22 mediated HG-inhibited autophagy and the synthesis of Col IV and α-SMA.