Markers of Local Inflammation and Bone Resorption in the Acute Diabetic Charcot Foot
Table 2
Levels of inflammation markers in local venous samples in the acute Charcot foot (CF(v)), the healthy foot (non-CF(v)), and arterial samples from the a. radialis. Measurements listed before () and after () external cooling of both feet with ice water.
Sampling site
fsRANK-L (pmol/L)
Arterial
0.14 ± 0.12
0.13 ± 0.11
CF(v)
0.13 ± 0.11
0.14 ± 0.11
non-CF(v)
0.13 ± 0.11
0.14 ± 0.13
OPG (pmol/L)
Arterial
6.5 ± 5.4
6.6 ± 5.1
CF(v)
6.4 ± 5.8
7.3 ± 5.9
non-CF(v)
6.3 ± 5.5
7.5 ± 6.1
IL-6 (pg/mL)
Arterial
7.31 ± 6.88
6.25 ± 5.21
CF(v)
14.56 ± 14.27
16.29 ± 11.45
non-CF(v)
7.71 ± 7.07
7.93 ± 5.70
IL-8 (pg/mL)
Arterial
15.6 ± 7.9
13.1 ± 6.3
CF(v)
13.4 ± 4.4
12.1 ± 6.3
non-CF(v)
14.5 ± 9.6
11.5 ± 4.7
sRAGE (ng/L)
Arterial
845 ± 266
860 ± 247
CF(v)
833 ± 292
878 ± 298
non-CF(v)
827 ± 252
911 ± 293
AGEs (ng/mL)
Arterial
6.2 ± 7.7
5.4 ± 7.4
CF(v)
5.7 ± 6.8
7.9 ± 7.1
non-CF(v)
5.9 ± 7.2
8.4 ± 8.4
Data listed as mean ± 1 SD. fsRANKL = free soluble receptor activator of nuclear factor-κB; OPG = osteoprotegerin; IL-6/IL-8 = interleukin 6/interleukin 8; sRAGE = soluble receptor for advanced glycation end products; AGEs = advanced glycation end products.
