Research Article
Five-Year Predictors of Insulin Initiation in People with Type 2 Diabetes under Real-Life Conditions
Table 2
Multivariate Cox regression analyses for insulin treatment at follow-up.
| Patients with complete data | Model 1 | Model 2 | Model 3 | Model 4 | | | | | Hazard ratio | | Hazard ratio | | Hazard ratio | | Hazard ratio | |
| Male sex | 1.037 | <0.001 | 1.035 | 0.002 | 0.993 | 0.724 | 0.985 | 0.587 | Age (by 10 years) | 0.955 | <0.001 | 0.958 | <0.001 | 0.970 | 0.014 | 0.970 | 0.052 | Duration of diabetes (by 10 years) | 1.315 | <0.001 | 1.332 | <0.001 | 1.350 | <0.001 | 1.363 | <0.001 | HbA1c (by 1%) | 1.264 | <0.001 | 1.260 | <0.001 | 1.243 | <0.001 | 1.241 | <0.001 | Nonproliferative retinopathy | 1.287 | <0.001 | 1.288 | <0.001 | 1.256 | <0.001 | 1.277 | <0.001 | Proliferative retinopathy | 1.436 | <0.001 | 1.392 | <0.001 | 1.441 | <0.001 | 1.547 | <0.001 | eGFR below 90 (by 10 ml/min/1.73 m2) | 1.157 | <0.001 | 1.139 | <0.001 | 1.122 | <0.001 | 1.121 | <0.001 | Triglycerides ≥ 150 mg/dl | | | 1.079 | <0.001 | 1.060 | 0.007 | 1.095 | 0.001 | HDL < 40 mg/dl (M), <50 mg/dl (F) | | | 1.100 | <0.001 | 1.103 | <0.001 | 1.124 | <0.001 | LDL ≥ 100 mg/dl | | | 0.819 | <0.001 | 0.863 | <0.001 | 0.861 | <0.001 | Systolic/diastolic BP ≥ 140/85 mmHg | | | 0.950 | <0.001 | 0.945 | 0.009 | 0.949 | 0.059 | Albuminuria | Normoalbuminuria | | | | | Reference | | Reference | | Microalbuminuria | | | | | 1.366 | <0.001 | 1.414 | <0.001 | Macroalbuminuria | | | | | 2.028 | <0.001 | 2.210 | <0.001 | BMI | <27 kg/m2 | | | | | | | Reference | | 27–30 kg/m2 | | | | | | | 0.882 | <0.001 | >30 kg/m2 | | | | | | | 0.834 | <0.001 | Serum uric acid in the top quintile | | | | | | | 1.046 | 0.209 | Lipid-lowering treatment | 0.912 | <0.001 | 0.901 | <0.001 | 0.867 | <0.001 | 0.855 | <0.001 | Antihypertensive treatment | 1.002 | 0.819 | 0.999 | 0.916 | 1.000 | 0.998 | 1.020 | 0.501 | Aspirin | 1.007 | 0.598 | 1.010 | 0.515 | 1.002 | 0.948 | 1.002 | 0.966 | Antidiabetic treatment | Diet | Reference | | Reference | | Reference | | Reference | | Biguanides and sulphonylureas | 3.860 | <0.001 | 3.963 | <0.001 | 3.581 | <0.001 | 3.511 | <0.001 | Sulphonylureas | 2.874 | <0.001 | 2.950 | <0.001 | 2.806 | <0.001 | 2.804 | <0.001 | Glitazones | 1.649 | <0.001 | 1.691 | <0.001 | 1.469 | 0.011 | 1.534 | 0.031 | Biguanides | 1.286 | <0.001 | 1.283 | <0.001 | 1.188 | 0.004 | 1.209 | 0.012 |
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Hazard ratios from multivariate Cox proportional hazard models for insulin treatment during follow-up.
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