Research Article

Identification of Potential Therapeutic Targets in the Liver of Pioglitazone-Treated Type 2 Diabetes Sprague-Dawley Rats via Expression Profile Chip and iTRAQ Assay

Table 1

KEGG pathway enrichment via gene expression profile chip (DM versus Pio).

NumberPathway IDPathway value

1ko03008Ribosome biogenesis in eukaryotes2.92E − 02
2ko04977Vitamin digestion and absorption4.21E − 02
3ko04141Protein processing in endoplasmic reticulum1.21E − 01
4ko00051Fructose and mannose metabolism1.48E − 01
5ko00790Folate biosynthesis1.62E − 01
6ko00071Fatty acid metabolism1.69E − 01
7ko00970Aminoacyl-tRNA biosynthesis1.69E − 01
8ko04960Aldosterone-regulated sodium reabsorption1.69E − 01
9ko03040Spliceosome1.71E − 01
10ko04612Antigen processing and presentation1.85E − 01