Simvastatin-Induced Insulin Resistance May Be Linked to Decreased Lipid Uptake and Lipid Synthesis in Human Skeletal Muscle: the LIFESTAT Study

Table 1

Subject characteristics.

	Patients ()	Controls ()
Age (years)	45 ± 2	45 ± 1
Treatment time (years)	5 ± 1	—
Weight (kg)	93 ± 4	91 ± 4
BMI (kg/m^2)	27 ± 1	27 ± 1
Body fat (%)	28 ± 2	27 ± 2
LBM (kg)	63 ± 2	63 ± 2
VO2max (ml O2/min/kg BW)	38 ± 1	40 ± 2
IPAQ (kcal/week)	3455 ± 672	3128 ± 709
HbA1c (%)	5.7 ± 0.1	5.2 ± 0.1
NEFA (μmol/l)	455 ± 59	412 ± 100
TG (mmol/l)	1.4 ± 0.2	1.3 ± 0.2
Cholesterol (mmol/l)	4.8 ± 0.3	4.3 ± 0.2
LDL (mmol/l)	3.1 ± 0.3	2.7 ± 0.2
HDL (mmol/l)	1.3 ± 0.1	1.2 ± 0.1
Adiponectin (ng/ml)	6004 ± 503	5065 ± 637
Leptin (pg/ml)	4411 ± 750	4139 ± 859
SI (mg·l^2/mmol·mU·min)	39 ± 6	54 ± 4

Data are mean ± SE. Abbreviations: BW, body weight; HbA1c, glycated hemoglobin; HDL, high-density lipoprotein; IPAQ, International Physical Activity Questionnaire; LBM, lean body mass; LDL, low-density lipoprotein; NEFA, nonesterified fatty acids; SI, peripheral insulin sensitivity (Cederholm index); TG, triglycerides; VO_2max, maximal oxygen uptake. . Data has previously been published [22].