Food Intake and Core Body Temperature of Pups and Adults in a db Mouse Line Deficient in the Long Form of the Leptin Receptor without Misty Mutation

Figure 2

Expression of genes related to food intake and thermogenesis regulation in the hypothalamus and brown adipose tissue (BAT). Expression of genes in the hypothalamus are shown (a). Agrp (a1), Npy (a2), Cart (a3), and Pomc (a4) expression levels are displayed relative to Gapdh mRNA levels. Expression of genes related to thermogenesis in BAT (b). Ucp1 (b1) and Pparγ (b2) mRNA levels are displayed relative to Gapdh mRNA levels. The sample size of all groups is 7-8. The values are the mean + SE. The values are expressed as the fold change relative to WT mice at the respective age (all values were set to 1.0). Open columns and closed columns represent WT (+/+) mice and db/db mice, respectively. The data were analyzed statistically by unpaired Student’s t-test. , compared with WT mice at the respective age.