Ranirestat Improved Nerve Conduction Velocities, Sensory Perception, and Intraepidermal Nerve Fiber Density in Rats with Overt Diabetic Polyneuropathy

Figure 1

Amelioration of nerve conduction velocities in hindlimbs of diabetic rats treated with ranirestat. Nerve conduction velocities decreased in the diabetic rats 12 weeks after induction of diabetes (a, c). The decrease was diminished in the diabetic rats after 6-week treatment with ranirestat (b, d). MNCV: motor nerve conduction velocity; SNCV: sensory nerve conduction velocity; 12 w: 12 weeks after induction of diabetes; 18 w: 18 weeks after induction of diabetes; N: nondiabetic rats; D: diabetic rats; N-veh: nondiabetic rats treated with placebo; D-veh: diabetic rats treated with placebo; N-rani: nondiabetic rats treated with ranirestat; D-rani: diabetic rats treated with ranirestat; D-epa: diabetic rats treated with epalrestat. compared with N or N-veh and ^† compared with D-veh. at 12 w, in groups treated with placebo or ranirestat, and in D-epa. Bold horizontal line in each group demonstrates an average value.

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