Pioglitazone Ameliorates Atorvastatin-Induced Islet Cell Dysfunction through Activation of FFA1 in INS-1 Cells

Figure 1

Effect of atorvastatin on basal insulin secretion and potassium-stimulated insulin secretion in INS-1 cells. (a) 20 μM atorvastatin increased basal insulin secretion. (b) 2 μM and 20 μM atorvastatin significantly reduced the potassium-stimulated insulin secretion after 24 h of incubation. (c) qRT-PCR assay analysis of insulin expression in INS-1 cells treated with different concentrations of atorvastatin for 24 h. Values presented are the deviations of three independent experiments. and compared to 0 μM atorvastatin treatment.

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