TAK-875 Mitigates β-Cell Lipotoxicity-Induced Metaflammation Damage through Inhibiting the TLR4-NF-κB Pathway

Figure 3

The protective effect of TAK-875 on lipotoxicity was partially independent of GPR40. (a) The effect of down regulation of GPR40 on the TAK-875 in inhibiting PA-induced apoptosis, (b) improving BIS and GSIS, and (c) decreasing inflammation-related protein expression. ^a vs. NC group, ^c vs. 0.5 mmol/L PA group, and ^d vs. 0.5 mmol/L PA+100 nmol/L TAK-875 group.

(a)

(b)

(c)