Effects of Highly Absorbable Curcumin in Patients with Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mellitus

Table 2

Change of each parameter in patients treated with placebo.

Placebo	0M (0 month)	3M	6M	value for trend test	value
					0M vs. 3M	0M vs. 6M	3M vs. 6M
BMI (kg/m^2)				0.109	0.716	0.109	0.164
SBP (mmHg)				0.541	0.474	0.541	0.901
DBP (mmHg)				0.454	0.661	0.454	0.508
HbA1c (%)	6.1 [6.0, 6.7]	6.2 [5.9, 6.4]	6.3 [6.1, 6.6]	0.587	0.417	0.886	0.681
BS (mg/dL)	110.0 [99.5, 160.5]	112.0 [95.0, 139.0]	134.0 [109.5, 155.0]	0.850	0.705	0.723	0.017
TG (mg/dL)	144.0 [87.0, 198.5]	134.0 [93.8, 206.8]	118.0 [84.3, 232.8]	0.677	0.326	0.326	0.277
LDL-C (mg/dL)				0.992	0.041	0.992	0.183
HDL-C (mg/dL)				0.192	0.228	0.192	0.723
UA (mg/dL)				0.545	0.401	0.545	0.684
γ-GTP (IU/L)	29.0 [21.5, 49.5]	28.0 [24.0, 49.0]	32.0 [18.5, 55.0]	0.252	0.536	0.244	0.950
Cre (mg/dL)	0.8 [0.8, 0.9]	0.8 [0.7, 1.0]	0.8 [0.7, 1.0]	0.326	0.530	0.348	0.887
SAA-LDL (μg/mL)	5.0 [4.8, 8.0]	6.0 [4.0, 18.8]	5.0 [5.0, 8.5]	0.915	0.174	0.630	0.261
AT-LDL (μg/mL)	1.3 [1.0, 1.4]	1.4 [1.2, 1.6]	1.4 [1.1, 1.7]	0.017	0.071	0.024	0.942
Adiponectin (μg/mL)				0.302	0.159	0.302	0.706
Leptin (ng/mL)	5.1 [2.3, 7.0]	4.7 [3.3, 7.7]	4.0 [2.2, 6.6]	0.279	0.660	0.221	0.073
hs-CRP (mg/dL)	0.6 [0.4, 1.8]	0.8 [0.5, 4.2]	0.9 [0.5, 1.3]	0.385	0.730	0.778	0.551
CCr (mL/min/1.73m^2)	69.1 [54.2, 88.9]	74.1 [57.3, 92.7]	77.4 [59.7, 96.1]	0.723	0.569	0.438	0.733

BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; HbA1c: hemoglobin A1c; BS: blood sugar; TG: triglyceride; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; UA: uric acid; γ-GTP: γ-glutamyl transpeptidase; Cre: creatinine; SAA-LDL: serum amyloid A-LDL; AT-LDL: a1-antitrypsin-LDL; hs-CRP: high-sensitivity C-reactive protein; CCr: creatinine clearance.