Review Article

Oxidative Stress as the Main Target in Diabetic Retinopathy Pathophysiology

Table 1

Polymorphisms implicated in diabetic retinopathy. Many genes have been associated with diabetic retinopathy; some polymorphisms in them have, apparently, protective effects while others worsen its progression.

Author (year)PopulationPolymorphismConclusions

Aldose reductase (Alr)Abhary et.al. (2010) [102]Australianrs9640883Association with duration of diabetes rather than a direct association to DR
Wang et al. (2003) [115]ChineseRs759853 T alleleProtective effect against DR in DM type 1
Santos et al. (2003) [116]Euro-BrazilianALR C(-106)TNo association to DR
Nitric oxide synthase (NOS)Zhao et al. (2012) [114]ChineseNOS3 4b/aNegative association with DR (protective effect)
Cheema et al. (2012) [117]Asian Indianrs3138808No association with DR
Santos et al. (2012) [118]Caucasian-BrazilianNOS3b/aNo association to DR
Receptor for advanced glycation end products (RAGEs)Ng et al. (2012) [119]Malaysian-429T/C and -374T/ANo association with DR
Vanita (2014) [120]IndianGly82SerPositive association with DR
Yang et al. (2013) [121]ChineseGly82SerAssociated to DR risk
Vascular endothelial growth factor (VEGF)Kangas-Kontio et al. (2009) [122]Multiethnicrs3095039No association
Abhary et al. (2009) [123]Multiethnicrs3025021Positive association
Qiu et al. (2013) [124]Chinesers2010963Positive association
Gluthatione S-transferase (GST)Dadbinpour et al. (2013) [125]IranianGSTM1Positive association with DR
Manganese superoxide dismutase (MnSOD)Haghighi et al. (2015) [126]IranianA16VPositive association with DR
Vanita (2014) [120]IndianVal16AlaNo association with DR
Intercellular adhesion molecule1 (ICAM-1)Fan et al. (2015) [127]Asianrs5498Negative association with DR
Rs13306430Positive association with DR
Transforming growth factor beta 1 (TGF-β1)Rodrigues et al. (2015) [128]BrazilianRs1800471Positive association with DR
Bazzaz et al. (2014) [129]Caucasian+869 C/T
+915 G/C
No association with DR