The APOE3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis

Figure 1

Study design. Female E3L.GK^+/−, E3L, and GK^+/− mice were fed different diets throughout the study. Blood samples were drawn at weeks 0, 4, 8, 12, 18, 30, and 36 as depicted in grey. All mice were sacrificed at week 37. +glucose: 10% glucose drinking water.