Insulin Resistance, Type 1 and Type 2 Diabetes, and Related Complications: Current Status and Future Perspective
1Department of Physiology, College of Medicine, University of Saskatchewan Saskatoon, SK, Canada S7N 5E5
2Division of Cardiovascular Medicine, Department of Medicine, The Henry Ford Heart and Vascular Institute, 2799 West Grand Boulevard, Detroit, MI 48202-2689, USA
3Department of Pharmacology, Center for Integrative Medicine and Center for Molecular Medicine (CIMMBA), University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Insulin Resistance, Type 1 and Type 2 Diabetes, and Related Complications: Current Status and Future Perspective
Description
The global escalation of obesity and diabetes in developed and developing nations poses a great health challenge. Obesity is one of the major causes of type 2 diabetes. Type 1 diabetes is primarily due to the autoimmune-mediated destruction of pancreatic beta-cell leading to insulin deficiency. This is usually accompanied by alterations in lipid metabolism, enhanced hyperglycemia-mediated oxidative stress, endothelial cell dysfunction, and apoptosis. Similarly, in type 2 diabetes, increased glucotoxicity, lipotoxicity, endoplasmic reticulum-induced stress, and apoptosis lead to the progressive loss of beta-cells. While type 1 diabetes is characterized by the presence of beta-cell autoantibodies, a combination of peripheral insulin resistance and dysfunctional insulin secretion by pancreatic beta-cells is implicated in the pathogenesis of type 2 diabetes. Although insulin resistance has traditionally been associated with type 2 diabetes, mounting evidence indicates that the incidence of insulin resistance in type 1 diabetes is increasing; therefore, novel mechanistic approaches deciphering insulin resistance are needed. Many pathophysiological factors are implicated in insulin resistance. Although the exact natures of these factors are not completely understood, it is widely accepted that oxidative stress, inflammation, and genetic, habitual, environmental and other epigenetic factors play a significant role.
In the past decade, significant strides have been made in elucidating important mechanisms associated with insulin resistance, overt diabetes, and related cardiometabolic diseases. However, more intense research is still needed for a more comprehensive understanding of the pathophysiological profile of insulin resistance in diabetes, especially in situations where diabetes is comorbid with other chronic diseases.
Therefore, this special issue will welcome research and review papers that address a broad range of mechanisms associated with insulin resistance, type 1 diabetes, type 2 diabetes, and related cardiometabolic complications. Potential topics include, but are not limited to:
- Role of epigenetics in type 1 and type 2 diabetes
- Novel mechanisms of insulin resistance and dysfunctional glucose metabolism in type 1 and type 2 diabetes
- Novel prognostic and therapeutic interventions
- Role of adiposity in insulin signaling and cardiometabolic complications
- Macrovascular and microvascular complications of diabetic complications including cardiomyopathy, nephropathy, vasculopathy, and neuropathy
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