Biomarker Research in Glucose Disorders: Current Concepts and Clinical Applications
1Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 7RH, UK
2Department of Health Sciences, Princess Road West, University of Leicester, Leicester LE1 7RH, UK
3BHF Glasgow Cardiovascular Center, Wolfson medical school building, University Avenue, Glasgow G12 8QQ, UK
4Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands
Biomarker Research in Glucose Disorders: Current Concepts and Clinical Applications
Description
Existing risk factors fail to explain the increased frequency of cardiovascular disease in people with type 2 diabetes. The identification of new vasculopathic biomarkers in early glucose disorders may assist our understanding of the disease and its complications. Emerging functional and structural biomarkers have the potential to revolutionize current approaches to the prevention, treatment, and risk stratification of vascular disease. We invite articles which utilize well-validated surrogates of endothelial dysfunction, arterial stiffness, and inflammation in diabetes, impaired glucose tolerance, or impaired fasting glycaemia. Cross-sectional prospective or even interventional designs with biomarker outcomes would be considered. Of particular interest are interracial comparisons underpinning theories of cardiometabolic disease susceptibility in Asians and Afro-Caribbeans. Potential topics include, but are not limited to:
- Candidate markers of hemodynamic/endothelial function associating with or predicting vascular complications in impaired glucose regulation
- Putative mechanisms of premature conduit vessel sclerosis in diabetes and implications for future biomarker development
- Epidemiological inflammatory biomarker studies within ethnic groups at risk of cardiometabolic disease
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