Journal of Dental Surgery http://www.hindawi.com The latest articles from Hindawi Publishing Corporation © 2014 , Hindawi Publishing Corporation . All rights reserved. Factors Associated with Bone Level Alterations at Implants with Inner-Cone Connection and Platform Switching Sun, 23 Feb 2014 08:35:58 +0000 http://www.hindawi.com/journals/jds/2014/685803/ Purpose. This retrospective cohort study evaluated factors for peri-implant bone level changes (ΔIBL) associated with an implant type with inner-cone implant-abutment connection, rough neck surface, and platform switching (AT). Materials and Methods. All AT placed at the Department of Prosthodontics of the University of Bern between January 2004 and December 2005 were included in this study. All implants were examined by single radiographs using the parallel technique taken at surgery (T0) and obtained at least 6 months after surgery (T1). Possible influencing factors were analysed first using t-test (normal distribution) or the nonparametric Wilcoxon test (not normal distribution), and then a mixed model q variance analysis was performed. Results. 43 patients were treated with 109 implants. Five implants in 2 patients failed (survival rate: 95.4%). Mean ΔIBL in group 1 (T1: 6–12 months after surgery) was  mm and  mm in group 2 (T1: >12 months after surgery) (). Greater implant insertion depth in diameter 3.5 mm implants might be associated with increased ΔIBL (). In the anterior region, the bone alteration was more pronounced (). Conclusions. ΔIBL values indicated that the implant system used in this study fulfilled implant success criteria. Renzo Bassetti, Simone Reischel, Sükran Öztürk, Mario Bassetti, Regina Mericske-Stern, and Norbert Enkling Copyright © 2014 Renzo Bassetti et al. All rights reserved. Epidermal Growth Factor Receptor Protein: A Biological Marker for Oral Precancer and Cancer Sun, 09 Feb 2014 14:13:01 +0000 http://www.hindawi.com/journals/jds/2014/158709/ Background. The aim of the present paper was to study the expression and overexpression of EGFR in oral leukoplakia and cancer and at the same time assess the expression of EGFR in various histological grades of oral leukoplakia and OSCC in the Indian subcontinent. Methods. The study was conducted with routine H&E and IHC staining on 40 archival tissues. Results. Positive EGFR staining was present in all the cases 100% (30/30) out of which 7 (46.7%) cases of OSCC showed >75% EGFR expression and 8 (53.3%) cases of oral leukoplakia showed 25% EGFR expression. A statistically significant correlation was found in OSCC, OL and controls. Conclusions. EGFR may represent a promising target for novel molecular cancer therapies. EGFR expression levels in the premalignant lesion appear to be a sensitive factor in predicting the neoplastic potential of dysplastic tissues. This suggests that EGFR may serve as a biological marker to identify high-risk subgroups and guide prophylactic therapy. Ashish Mahendra, Balasundari Shreedhar, Mala Kamboj, Arun Singh, Abhishek Singh, Ashutosh Agrawal, Sachin Kumar, and Arpita Kabiraj Copyright © 2014 Ashish Mahendra et al. All rights reserved. Aloe vera: An Ancient Herb for Modern Dentistry—A Literature Review Tue, 21 Jan 2014 12:41:41 +0000 http://www.hindawi.com/journals/jds/2014/210463/ Objectives. To review composition, actions, and clinical applications of Aloe vera plant in dentistry and to establish its effectiveness as an invaluable adjunct in the treatment of dental diseases. Method. A manual and electronic literature (MEDLINE, Cochrane Central Register of Controlled Trials, and Google Scholar) search was performed up to July 2013 for in vitro and in vivo studies and research presenting clinical, microbiological, immunological, and patient-centered data to validate the efficacy of Aloe vera gel in dentistry. A total of 38 titles, abstracts, and full-text studies were selected and reviewed. Aloe vera has various medicinal properties like anti-inflammatory, antibacterial, antiviral, and antitumor which accelerates wound healing and helps in treating various lesions in oral cavity. Benefits associated with Aloe vera have been attributed to the polysaccharides contained in the gel of the leaves. Conclusion. The pharmacological attributes of Aloe vera have been revalidated in modern sciences through various in vivo and in vitro studies. The herb has immense potential as a dental therapeutic. Even though Aloe vera is a promising herb with various clinical applications in medicine and dentistry, more clinical research needs to be undertaken especially to validate and explain the action of acemannan hydrogel in accelerating the healing of aphthous ulcers and to validate the efficacy of Aloe gel on plaque and gingivitis, so that it can be established in the field of dentistry. Arbaz Sajjad and Samia Subhani Sajjad Copyright © 2014 Arbaz Sajjad and Samia Subhani Sajjad. All rights reserved.