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Journal of Electrical and Computer Engineering
Volume 2011 (2011), Article ID 697543, 10 pages
Research Article

Time-Varying Procedures for Insulin-Dependent Diabetes Mellitus Control

1CONICET and Center of Systems and Control, Department of Mathematics, Buenos Aires Institute of Technology (ITBA), Avenida E. Madero 399, C1106ACD, Buenos Aires, Argentina
2CONICET and Department of Electrical Engineering, ITBA, Buenos Aires, Argentina
3Catalonia Institute for Energy Research (IREC), Josep Pla, B2, Pl. Baixa, 08019 Barcelona, Spain

Received 12 October 2010; Revised 28 January 2011; Accepted 26 March 2011

Academic Editor: Eldon D. Lehmann

Copyright © 2011 R. S. Sánchez Peña et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This work considers the problem of automatically controlling the glucose level in insulin dependent diabetes mellitus (IDDM) patients. The objective is to include several important and practical issues in the design: model uncertainty, time variations, nonlinearities, measurement noise, actuator delay and saturation, and real time implementation. These are fundamental issues to be solved in a device implementing this control. Two time-varying control procedures have been proposed which take into consideration all of them: linear parameter varying (LPV) and unfalsified control (UC). The controllers are implemented with low-order dynamics that adapt continuously according to the glucose levels measured in real time in one case (LPV) and by controller switching based on the actual performance in the other case (UC). Both controllers have performed adequately under all these practical restrictions, and a discussion on pros and cons of each method is presented at the end.