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Journal of Environmental and Public Health
Volume 2012 (2012), Article ID 258981, 15 pages
http://dx.doi.org/10.1155/2012/258981
Review Article

Plasma Levels of Polychlorinated Biphenyls, Non-Hodgkin Lymphoma, and Causation

1Department of Public Health and Preventive Medicine, Oregon Health & Science University School of Medicine, 1234 SW 18th Avenue, Suite 102, Portland, OR 97205, USA
2Regenerative Bioengineering Laboratory, Department of Mechanical & Materials Engineering, Portland State University, 1930 SW 4th Avenue, Suite 400, Portland, OR 97201, USA

Received 21 June 2011; Accepted 9 November 2011

Academic Editor: David O. Carpenter

Copyright © 2012 Michael D. Freeman and Sean S. Kohles. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Agency for Toxic Substances and Disease Registry (ATSDR), Toxicological Profile for Polychlorinated Biphenyls (PCBs), Department of Health and Human Services, Atlanta, Ga, USA, 2000.
  2. National Toxicology Program (NTP), Report on Carcinogens, Substance Profiles, CAS no. 1336-36-3, Polychlorinated Biphenyls (PCBs), 11th edition, 2004.
  3. Environmental Protection Agency (EPA), Polychlorinated Biphenyls (PCBs), http://www.epa.gov/epawaste/hazard/tsd/pcbs/pubs/about.htm.
  4. Environmental Protection Agency (EPA), “Health assessment document for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. Prepared by the Office of Health and Environmental Assessment, Office of Research and Development, Washington, DC. External Review Draft, 3 vol,” Tech. Rep. EPA/600/BP–92/001c, Available from the National Technical Information Service, Springfield, VA, USA, PB 94- 205457, 1994.
  5. S. Safe, “Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs),” Critical Reviews in Toxicology, vol. 21, no. 1, pp. 51–88, 1990. View at Scopus
  6. Monsanto, Polychlorinated Biphenyls (PCBs), A Report on Uses, Environmental and Health Effects and Disposal, Monsanto Company Public Relations Department, 1979.
  7. V. J. Cogliano, “Assessing the cancer risk from environmental PCBs,” Environmental Health Perspectives, vol. 106, no. 6, pp. 317–323, 1998. View at Scopus
  8. B. L. Johnson, H. E. Hicks, W. Cibulas et al., Public Health Implications of Exposure to Polychlorinated Biphenyls (PCBs), Agency for Toxic Substances and Disease Registry, 1999.
  9. S. Safe, “Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: progress and problems,” Environmental Health Perspectives, vol. 100, pp. 259–268, 1992. View at Scopus
  10. L. P. Hanrahan, C. Falk, H. A. Anderson et al., “Serum PCB and DDE levels of frequent Great Lakes sport fish consumers—a first look,” Environmental Research A, vol. 80, no. 2, pp. S26–S37, 1999. View at Publisher · View at Google Scholar · View at Scopus
  11. J. D. McKinney and C. L. Waller, “Polychlorinated biphenyls as hormonally active structural analogues,” Environmental Health Perspectives, vol. 102, no. 3, pp. 290–297, 1994. View at Scopus
  12. Environmental Protection Agency (EPA), “PCBs: cancer dose-response assessment and application to environmental mixtures,” Tech. Rep. EPA/600/P–96/001F, National Center for Environmental Assessment, Office of Research and Development, Washington Office, 1996.
  13. R. D. Kimbrough, R. A. Squire, R. E. Linder, J. D. Strandberg, R. J. Montalli, and V. W. Burse, “Induction of liver tumors in Sherman strain female rats by polychlorinated biphenyl aroclor 1260,” Journal of the National Cancer Institute, vol. 55, no. 6, pp. 1453–1459, 1975.
  14. D. H. Norback and R. H. Weltman, “Polychlorinated biphenyl induction of hepatocellular carcinoma in the Sprague-Dawley rat,” Environmental Health Perspectives, vol. 60, pp. 97–105, 1985. View at Scopus
  15. E. Schaeffer, H. Greim, and W. Goessner, “Pathology of chronic polychlorinated biphenyl (PCB) feeding in rats,” Toxicology and Applied Pharmacology, vol. 75, no. 2, pp. 278–288, 1984. View at Scopus
  16. M. J. Brunner, T. M. Sullivan, A. W. Singer et al., “An assessment of the chronic toxicity and oncogenicity of Aroclor-1016, Aroclor-1242, Aroclor-1254, and Aroclor-1260 administered in diet to rats,” Study no. SC920192, Battelle Memorial Institute, 1996.
  17. D. P. Brown, “Mortality of workers exposed to polychlorinated biphenyls—an update,” Archives of Environmental Health, vol. 42, no. 6, pp. 333–339, 1987. View at Scopus
  18. R. Recio-Vega, V. Velazco-Rodriguez, G. Ocampo-Gómez, S. Hernandez-Gonzalez, P. Ruiz-Flores, and F. Lopez-Marquez, “Serum levels of polychlorinated biphenyls in Mexican women and breast cancer risk,” Journal of Applied Toxicology, vol. 31, no. 3, pp. 270–278, 2011. View at Publisher · View at Google Scholar · View at PubMed
  19. R. P. Gallagher, A. C. Macarthur, T. K. Lee et al., “Plasma levels of polychlorinated biphenyls and risk of cutaneous malignant melanoma: a preliminary study,” International Journal of Cancer, vol. 128, no. 8, pp. 1872–1880, 2011. View at Publisher · View at Google Scholar · View at PubMed
  20. G. Maifredi, F. Donato, M. Magoni et al., “Polychlorinated biphenyls and non-Hodgkin's lymphoma: a case-control study in Northern Italy,” Environmental Research, vol. 111, no. 2, pp. 254–259, 2011. View at Publisher · View at Google Scholar · View at PubMed
  21. S. L. Schantz, “Developmental neurotoxicity of PCBs in humans: what do we know and where do we go from here?” Neurotoxicology and Teratology, vol. 18, no. 3, pp. 217–227, 1996. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Levin, B. Morsey, C. Mori, P. R. Nambiar, and S. De Guise, “Non-coplanar PCB-mediated modulation of human leukocyte phagocytosis: a new mechanism for immunotoxicity,” Journal of Toxicology and Environmental Health A, vol. 68, no. 22, pp. 1977–1993, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. M. K. Selgrade, “Immunotoxicity—the risk is real,” Toxicological Sciences, vol. 100, no. 2, pp. 328–332, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  24. A. E. Grulich, C. M. Vajdic, and W. Cozen, “Altered immunity as a risk factor for non-Hodgkin lymphoma,” Cancer Epidemiology Biomarkers and Prevention, vol. 16, no. 3, pp. 405–408, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. E. A. Engels, J. R. Cerhan, M. S. Linet et al., “Immune-related conditions and immune-modulating medications as risk factors for non-Hodgkin's lymphoma: a case-control study,” American Journal of Epidemiology, vol. 162, no. 12, pp. 1153–1161, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. A. J. De Roos, P. Hartge, J. H. Lubin et al., “Persistent organochlorine chemicals in plasma and risk of non-Hodgkin's lymphoma,” Cancer Research, vol. 65, no. 23, pp. 11214–11226, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. M. Merhi, H. Raynal, E. Cahuzac, F. Vinson, J. P. Cravedi, and L. Gamet-Payrastre, “Occupational exposure to pesticides and risk of hematopoietic cancers: meta-analysis of case-control studies,” Cancer Causes and Control, vol. 18, no. 10, pp. 1209–1226, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. E. N. Marieb, Human Anatomy and Physiology, Addison Wesley Longman, 5th edition, 2001.
  29. J. Ferlay, F. Bray, P. Pisani, and D. M. Parkin, GLOBOCAN 2000: Cancer Incidence, Mortality and Prevalence Worldwide, International Agency for Research on Cancer, Lyon, France, 2001.
  30. M. Melbye and D. Trichopoulos, “Non-Hodgkin's lymphomas,” in Textbook of Cancer Epidemiology, H. O. Adami, D. Hunter, and D. Trichopoulos, Eds., pp. 535–555, Oxford University Press, New York, NY, USA, 2002.
  31. L. A. G. Ries, D. Melbert, M. Krapcho, et al., “SEER cancer statistics review, 1975–2005,” National Cancer Institute, based on November 2007 SEER data submission, posted to the SEER web site, 2008, http://seer.cancer.gov/csr/1975_2005/.
  32. S. F. Altekruse, C. L. Kosary, M. Krapcho, et al., Eds., “SEER cancer statistics review, 1975–2007,” National Cancer Institute, Bethesda, Md, USA, based on November 2009 SEER data submission, posted to the SEER web site, 2010, http://seer.cancer.gov/csr/1975_2007/.
  33. L. Hardell, “Pesticides, soft-tissue sarcoma and non-Hodgkin lymphoma—historical aspects on the precautionary principle in cancer prevention,” Acta Oncologica, vol. 47, no. 3, pp. 347–354, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. L. Hardell and M. Eriksson, “Is the decline of the increasing incidence of non-Hodgkin lymphoma in Sweden and other countries a result of cancer preventive measures,” Environmental Health Perspectives, vol. 111, no. 14, pp. 1704–1706, 2003. View at Scopus
  35. N. E. Mueller, A. Mohar, and A. Evans, “Viruses other than HIV and non-Hodgkin's lymphoma,” Cancer Research, vol. 52, no. 19, pp. 5479s–5481s, 1992. View at Scopus
  36. S. G. Fisher and R. I. Fisher, “The epidemiology of non-Hodgkin's lymphoma,” Oncogene, vol. 23, no. 38, pp. 6524–6534, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  37. S. A. Kafafi, H. Y. Afeefy, A. H. Ali, H. K. Said, and G. A. Kafafi, “Binding of polychlorinated biphenyls to the aryl hydrocarbon receptor,” Environmental Health Perspectives, vol. 101, no. 5, pp. 422–428, 1993. View at Scopus
  38. N. Tijet, P. C. Boutros, I. D. Moffat, A. B. Okey, J. Tuomisto, and R. Pohjanvirta, “Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries,” Molecular Pharmacology, vol. 69, no. 1, pp. 140–153, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  39. C. L. Rocca, S. Alivernini, M. Badiali et al., “TEQS and body burden for PCDDs, PCDFs, and dioxin-like PCBs in human adipose tissue,” Chemosphere, vol. 73, no. 1, pp. 92–96, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  40. N. Rothman, K. P. Cantor, A. Blair et al., “A nested case-control study of non-Hodgkin lymphoma and serum organochlorine residues,” The Lancet, vol. 350, no. 9073, pp. 240–244, 1997. View at Publisher · View at Google Scholar · View at Scopus
  41. L. S. Engel, F. Laden, A. Andersen et al., “Polychlorinated biphenyl levels in peripheral blood and non-Hodgkin's lymphoma: a report from three cohorts,” Cancer Research, vol. 67, no. 11, pp. 5545–5552, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  42. J. J. Spinelli, C. H. Ng, J. P. Weber et al., “Organochlorines and risk of non-Hodgkin lymphoma,” International Journal of Cancer, vol. 121, no. 12, pp. 2767–2775, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  43. L. Hardell, M. Eriksson, G. Lindström et al., “Case-control study on concentrations of organohalogen compounds and titers of antibodies to Epstein-Barr virus antigens in the etiology of non-Hodgkin lymphoma,” Leukemia and Lymphoma, vol. 42, no. 4, pp. 619–629, 2001. View at Scopus
  44. L. Hardell, H. Bjornfoth, K. Hardell, B. van Bavel, G. Lindstrom, and M. Carlberg, “Concentrations of organohalogen compounds and titers of antibodies to Epstein-Barr virus antigens and the risk for non-Hodgkin lymphoma,” Organohalogen Compounds, vol. 68, pp. 2535–2528, 2006.
  45. K. Hardell, M. Carlberg, L. Hardell et al., “Concentrations of organohalogen compounds and titres of antibodies to Epstein-Barr virus antigens and the risk for non-Hodgkin lymphoma,” Oncology Reports, vol. 21, no. 6, pp. 1567–1576, 2009. View at Publisher · View at Google Scholar
  46. P. Cocco, P. Brennan, A. Ibba et al., “Plasma polychlorobiphenyl and organochlorine pesticide level and risk of major lymphoma subtypes,” Occupational and Environmental Medicine, vol. 65, no. 2, pp. 132–140, 2008. View at Publisher · View at Google Scholar · View at PubMed
  47. K. A. Bertrand, D. Spiegelman, J. C. Aster et al., “Plasma organochlorine levels and risk of non-hodgkin lymphoma in a cohort of men,” Epidemiology, vol. 21, no. 2, pp. 172–180, 2010. View at Publisher · View at Google Scholar · View at PubMed
  48. F. Laden, K. A. Bertrand, L. Altshul, J. C. Aster, S. A. Korrick, and S. K. Sagiv, “Plasma organochlorine levels and risk of non-Hodgkin lymphoma in the nurses' health study,” Cancer Epidemiology Biomarkers and Prevention, vol. 19, no. 5, pp. 1381–1384, 2010. View at Publisher · View at Google Scholar · View at PubMed
  49. P. J. E. Quintana, R. J. Delfino, S. Korrick et al., “Adipose tissue levels of organochlorine pesticides and polychlorinated biphenyls and risk of non-Hodgkin's lymphoma,” Environmental Health Perspectives, vol. 112, no. 8, pp. 854–861, 2004. View at Scopus
  50. M. M. Prince, M. J. Hein, A. M. Ruder, M. A. Waters, P. A. Laber, and E. A. Whelan, “Update: cohort mortality study of workers highly exposed to polychlorinated biphenyls (PCBs) during the manufacture of electrical capacitors, 1940–1998,” Environmental Health, vol. 5, article 13, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  51. M. M. Prince, A. M. Ruder, M. J. Hein et al., “Mortality and exposure response among 14,458 electrical capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs),” Environmental Health Perspectives, vol. 114, no. 10, pp. 1508–1514, 2006. View at Publisher · View at Google Scholar · View at Scopus
  52. A. M. Ruder, M. J. Hein, N. Nilsen et al., “Mortality among workers exposed to polychlorinated biphenyls (PCBs) in an electrical capacitor manufacturing plant in Indiana: an update,” Environmental Health Perspectives, vol. 114, no. 1, pp. 18–23, 2006. View at Publisher · View at Google Scholar · View at Scopus
  53. J. S. Colt, R. K. Severson, J. Lubin et al., “Organochlorines in carpet dust and non-Hodgkin lymphoma,” Epidemiology, vol. 16, no. 4, pp. 516–525, 2005. View at Publisher · View at Google Scholar · View at Scopus
  54. L. M. Morton, S. S. Wang, W. Cozen et al., “Etiologic heterogeneity among non-Hodgkin lymphoma subtypes,” Blood, vol. 112, no. 13, pp. 5150–5160, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  55. M. D. Freeman and S. S. Kohles, “An evaluation of applied biomechanics as an adjunct to systematic specific causation in forensic medicine,” Wiener Medizinische Wochenschrift, vol. 161, no. 19-20, pp. 458–468, 2011. View at Publisher · View at Google Scholar · View at PubMed
  56. M. D. Freeman and S. S. Kohles, “Application of the Hill criteria to the causal association of post-traumatic headache with assault,” Egyptian Journal of Forensic Science, vol. 1, no. 1, pp. 35–40, 2011.
  57. S. Loue, Forensic Epidemiology: Integrating Public Health and Law Enforcement, Jones and Bartlett Publishers, Boston, Mass, USA, 2010.
  58. Restatement (Third) of Torts: Liability for Physical and Emotional Harm § 28 cmt. c(3), 2010.
  59. Department of Health and Human Services (DHHS), Guidelines for Determining the Probability of Causation and Methods for Radiation Dose Reconstruction Under the Employees Occupational Illness Compensation Program Act of 2000, Federal Register. 42 CFR Part 81, 2000.
  60. F. M. Smith, Ed., Reference Manual on Scientific Evidence, Federal Judicial Center, 2nd edition, 2000.
  61. K. J. Rothman and S. Greenland, “Causation and causal inference in epidemiology,” American Journal of Public Health, vol. 95, supplement, pp. S144–S150, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  62. A. B. Hill, “The environment and disease: association or causation?” Proceedings of the Royal Society of Medicine, vol. 58, pp. 295–300, 1965. View at Scopus
  63. R. van Reekum, D. L. Streiner, and D. K. Conn, “Applying Bradford Hill's criteria for causation to neuropsychiatry: challenges and opportunities,” Journal of Neuropsychiatry and Clinical Neurosciences, vol. 13, no. 3, pp. 318–325, 2001. View at Publisher · View at Google Scholar · View at Scopus
  64. S. Lozano-Calderón, S. Anthony, and D. Ring, “The quality and strength of evidence for etiology: example of carpal tunnel syndrome,” Journal of Hand Surgery, vol. 33, no. 4, pp. 525–538, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  65. L. Batty, K. Holland-Elliott, and D. Rosenfeld, “Investigation of eye splash and needlestick incidents from an HIV-positive donor on an intensive care unit using root cause analysis,” Occupational Medicine, vol. 53, no. 2, pp. 147–150, 2003. View at Publisher · View at Google Scholar · View at Scopus
  66. M. D. Freeman, C. J. Centeno, and S. S. Kohles, “A systematic approach to clinical determinations of causation in symptomatic spinal disk injury following motor vehicle crash trauma,” PM & R, vol. 1, no. 10, pp. 951–956, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  67. L. C. Thygesen, G. S. Andersen, and H. Andersen, “A philosophical analysis of the Hill criteria,” Journal of Epidemiology and Community Health, vol. 59, no. 6, pp. 512–516, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  68. K. J. Rothman and S. Greenland, Modern Epidemiology, Lippincott-Raven, Philadelphia, Pa, USA, 2nd edition, 1998.
  69. J. Robins, S. Greenland, and N. E. Breslow, “A general estimator for the variance of the Mantel-Haenszel odds ratio,” American Journal of Epidemiology, vol. 124, no. 5, pp. 719–723, 1986. View at Scopus
  70. M. Pagano and K. Gauvreau, Principles of Biostatistics, Brooks/Cole, Belmont, Calif, USA, 2nd edition, 2000.
  71. F. Vinson, M. Merhi, I. Baldi, H. Raynal, and L. Gamet-Payrastre, “Exposure to pesticides and risk of childhood cancer: a meta-analysis of recent epidemiological studies,” Occupational and Environmental Medicine, vol. 68, no. 9, pp. 694–702, 2011. View at Publisher · View at Google Scholar · View at PubMed
  72. R. DerSimonian and N. Laird, “Meta-analysis in clinical trials,” Controlled Clinical Trials, vol. 7, no. 3, pp. 177–188, 1986. View at Scopus
  73. Interdepartmental Task Force on PCBs, Polychlorinated Biphenyls and the Environment, COM-72-10419, Departments of Agriculture, Commerce, Health, Education, and Welfare, Interior, Environmental Protection Agency, Washington, DC, USA, 1972.
  74. M. S. Wolff, D. Camann, M. Gammon, and S. D. Stellman, “Proposed PCB congener groupings for epidemiological studies,” Environmental Health Perspectives, vol. 105, no. 1, pp. 13–14, 1997. View at Scopus
  75. National Health and Nutrition Examination Survey (NHANES), Centers for Disease Control and Prevention (CDC), 2011.
  76. A. Golanski, “General causation at a crossroads in toxic tort cases,” Penn State Law Review, vol. 108, no. 2, pp. 479–523, 2003.
  77. M. S. Wolff, J. A. Britton, S. L. Teitelbaum et al., “Improving organochlorine biomarker models for cancer research,” Cancer Epidemiology Biomarkers and Prevention, vol. 14, no. 9, pp. 2224–2236, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  78. D. Baris, L. W. Kwak, N. Rothman et al., “Blood levels of organochlorines before and after chemotherapy among non-Hodgkin's lymphoma patients,” Cancer Epidemiology Biomarkers and Prevention, vol. 9, no. 2, pp. 193–197, 2000. View at Scopus