Plasma Levels of Polychlorinated Biphenyls, Non-Hodgkin Lymphoma, and Causation

Table 1

Summary of published case-control study populations examining risk of NHL and PCB blood content including those meta-analyzed in the present study. Summed or total PCB metrics shown here.

Study (notes, conc values)	Percentile	PCB conc (ng/g lipid)	Min conc	Max conc	Case sample size	Control sample size	OR	95% LCL	95% UCL	Meta-analysis inclusion
Rothman et al. 1997 (mean conc) [40]	Total				74	147
	1	526	247	641	10	37	1.00
	2	727	649	806	13	37	1.30	0.5	3.3	No
	3	924	814	1060	21	37	2.80	1.1	7.6
	4	1430	1070	2070	30	36	4.50	1.7	12.0
Engel et al., 2007 (Janus cohort, median conc) [41]	Total				190	190
	1	1048.3			44	48	1.00
	2	1398.3			48	47	1.10	0.7	2.0	Yes
	3	1674.9			38	48	1.00	0.5	1.9
	4	2148.2			60	47	1.70	0.8	3.4
Engel et al., 2007 (CLUE 1 cohort median conc) [41]	Total				74	147
	1	551.4			10	37	1.00
	2	726			13	37	1.10	0.7	2.0	Yes
	3	911.5			21	37	1.00	0.5	1.9
	4	1377.3			30	36	1.70	0.8	3.4
Spinelli et al., 2007 (Median conc) [42]	Total				403
	1		<100.9	100.9	81	115	1.00
	2		>100.9	155.6	103	114	1.41	0.93	2.14	Yes
	3		>155.6	220	77	115	1.11	0.71	1.74
	4		>220	6571	142	115	2.14	1.38	3.30
De Roos et al., 2005 [26]	Total				97	96
	1		<6.4	6.4	28	24	1.00
	2		>6.4	8.69	16	25	0.59	0.25	1.40	Yes
	3		>8.69	13.17	20	23	0.86	0.38	1.98
	4		>13.17		33	24	1.51	0.62	3.67
Laden et al., 2010 (median conc) [48]	Total				145	290
	1	406.9			33	72	1.00
	2	547.8			41	73	1.22	0.69	2.18	Yes
	3	678.0			41	73	1.22	0.69	2.18
	4	945.4			30	72	0.91	0.50	1.67
Hardell et al., 2001 (36 PCBs, mean conc) [53]	Total	1436	331	4706	82	83	1.00
	1		1296 (med)	4706	51	41	1.80	0.85	3.9	No
Hardell et al., 2001 (11 immunotoxic PCBs) [53]	Total	511	118	1598	82	83	1.00
	1		462 (med)	1598	57	40	3.20	1.4	7.4	No
Hardell et al., 2006; [54] Hardell et al., 2009 [43] (all PCBs, mean conc)	Total	860	102	4222	97	98	1.00
	1		762 (med)	4222	59	49	2.00	0.99	3.99	No
Hardell et al., 2006; [54] Hardell et al., 2009 [43] (11 immunotoxic PCBs)	Total	290	41	1297	97	98	1.00
	1		238 (med)	1297	54	49	1.50	0.8	3.0	No
Cocco et al., 2008 [46]	Total				174
	1		<200.42	200.42	41	51	1.00
	2		200.43	387.79	50	51	1.20	0.6	2.2	Yes
	3		387.8	576.36	33	50	0.70	0.3	1.4
	4		576.37	>576.37	50	51	1.00	0.5	2.0
Quintana et al., 2004 [44]	Total
	1		<1000	1000	79	184	1.00
	2		>1000	3000	50	151	1.05	0.63	1.76	No
	3		>3000		9	23	1.08	0.40	2.92
Bertrand et al., 2010 (median conc) [47]	Total				205	409
	1	518	163	617	33	81	1..00
	2	678	>617	742	31	82	0.92	0.51	1.60	Yes
	3	815	>742	894	34	82	1.00	0.60	1.80
	4	980	>894	1121	46	82	1.40	0.71	2.20
	5	1385	>1121	5322	61	82	1.90	0.94	2.90