Table 1: Summary of published case-control study populations examining risk of NHL and PCB blood content including those meta-analyzed in the present study. Summed or total PCB metrics shown here.

Study (notes, conc values) Percentile PCB conc (ng/g lipid) Min conc Max conc Case sample size Control sample size OR 95% LCL 95% UCL Meta-analysis inclusion Rothman et al. 1997 (mean conc) [40] Total 74 147 1 526 247 641 10 37 1.00 2 727 649 806 13 37 1.30 0.5 3.3 No 3 924 814 1060 21 37 2.80 1.1 7.6 4 1430 1070 2070 30 36 4.50 1.7 12.0 Engel et al., 2007 (Janus cohort, median conc) [41] Total 190 190 1 1048.3 44 48 1.00 2 1398.3 48 47 1.10 0.7 2.0 Yes 3 1674.9 38 48 1.00 0.5 1.9 4 2148.2 60 47 1.70 0.8 3.4 Engel et al., 2007 (CLUE 1 cohort median conc) [41] Total 74 147 1 551.4 10 37 1.00 2 726 13 37 1.10 0.7 2.0 Yes 3 911.5 21 37 1.00 0.5 1.9 4 1377.3 30 36 1.70 0.8 3.4 Spinelli et al., 2007 (Median conc) [42] Total 403 1 <100.9 100.9 81 115 1.00 2 >100.9 155.6 103 114 1.41 0.93 2.14 Yes 3 >155.6 220 77 115 1.11 0.71 1.74 4 >220 6571 142 115 2.14 1.38 3.30 De Roos et al., 2005 [26] Total 97 96 1 <6.4 6.4 28 24 1.00 2 >6.4 8.69 16 25 0.59 0.25 1.40 Yes 3 >8.69 13.17 20 23 0.86 0.38 1.98 4 >13.17 33 24 1.51 0.62 3.67 Laden et al., 2010 (median conc) [48] Total 145 290 1 406.9 33 72 1.00 2 547.8 41 73 1.22 0.69 2.18 Yes 3 678.0 41 73 1.22 0.69 2.18 4 945.4 30 72 0.91 0.50 1.67 Hardell et al., 2001 (36 PCBs, mean conc) [53] Total 1436 331 4706 82 83 1.00 1 1296 (med) 4706 51 41 1.80 0.85 3.9 No Hardell et al., 2001 (11 immunotoxic PCBs) [53] Total 511 118 1598 82 83 1.00 1 462 (med) 1598 57 40 3.20 1.4 7.4 No Hardell et al., 2006; [54] Hardell et al., 2009 [43] (all PCBs, mean conc) Total 860 102 4222 97 98 1.00 1 762 (med) 4222 59 49 2.00 0.99 3.99 No Hardell et al., 2006; [54] Hardell et al., 2009 [43] (11 immunotoxic PCBs) Total 290 41 1297 97 98 1.00 1 238 (med) 1297 54 49 1.50 0.8 3.0 No Cocco et al., 2008 [46] Total 174 1 <200.42 200.42 41 51 1.00 2 200.43 387.79 50 51 1.20 0.6 2.2 Yes 3 387.8 576.36 33 50 0.70 0.3 1.4 4 576.37 >576.37 50 51 1.00 0.5 2.0 Quintana et al., 2004 [44] Total 1 <1000 1000 79 184 1.00 2 >1000 3000 50 151 1.05 0.63 1.76 No 3 >3000 9 23 1.08 0.40 2.92 Bertrand et al., 2010 (median conc) [47] Total 205 409 1 518 163 617 33 81 1..00 2 678 >617 742 31 82 0.92 0.51 1.60 Yes 3 815 >742 894 34 82 1.00 0.60 1.80 4 980 >894 1121 46 82 1.40 0.71 2.20 5 1385 >1121 5322 61 82 1.90 0.94 2.90