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Journal of Environmental and Public Health
Volume 2012 (2012), Article ID 354151, 10 pages
http://dx.doi.org/10.1155/2012/354151
Clinical Study

Combination of Micronutrients for Bone (COMB) Study: Bone Density after Micronutrient Intervention

1Faculty of Medicine, University of Alberta, Edmonton, AB, Canada T6K 4C1
2Department of Family Medicine, University of Calgary, Calgary, AB, Canada T2N 1N4

Received 10 August 2011; Accepted 4 October 2011

Academic Editor: Gerry Schwalfenberg

Copyright © 2012 Stephen J. Genuis and Thomas P. Bouchard. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Along with other investigations, patients presenting to an environmental health clinic with various chronic conditions were assessed for bone health status. Individuals with compromised bone strength were educated about skeletal health issues and provided with therapeutic options for potential amelioration of their bone health. Patients who declined pharmacotherapy or who previously experienced failure of drug treatment were offered other options including supplemental micronutrients identified in the medical literature as sometimes having a positive impact on bone mineral density (BMD). After 12 months of consecutive supplemental micronutrient therapy with a combination that included vitamin D3, vitamin K2, strontium, magnesium and docosahexaenoic acid (DHA), repeat bone densitometry was performed. The results were analyzed in a group of compliant patients and demonstrate improved BMD in patients classified with normal, osteopenic and osteoporotic bone density. According to the results, this combined micronutrient supplementation regimen appears to be at least as effective as bisphosphonates or strontium ranelate in raising BMD levels in hip, spine, and femoral neck sites. No fractures occurred in the group taking the micronutrient protocol. This micronutrient regimen also appears to show efficacy in individuals where bisphosphonate therapy was previously unsuccessful in maintaining or raising BMD. Prospective clinical trials are required to confirm efficacy.