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Journal of Environmental and Public Health
Volume 2012 (2012), Article ID 727630, 7 pages
The Alkaline Diet: Is There Evidence That an Alkaline pH Diet Benefits Health?
University of Alberta, Suite No. 301, 9509-156 Street, Edmonton, AB, Canada T5P 4J5
Received 3 July 2011; Accepted 8 August 2011
Academic Editor: Janette Hope
Copyright © 2012 Gerry K. Schwalfenberg. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- A. Waugh and A. Grant, Anatomy and Physiology in Health and Illness, Churchill Livingstone Elsevier, Philadelphia, Pa, USA, 10th edition, 2007.
- University, Birmingham oAa, “Oceans reveal further impacts of climate change,” ScienceDaily, 2010.
- O. Hoegh-Guldberg, P. J. Mumby, A. J. Hooten et al., “Coral reefs under rapid climate change and ocean acidification,” Science, vol. 318, no. 5857, pp. 1737–1742, 2007.
- J. Dam-ampai SO and C. Nilnond, “Effect of cattle manure and dolomite on soil properties and plant growth in acid upland soils,” Songklanakarin Journal of Science and Technologh, vol. 27, supplement 3, pp. 727–737, 2005.
- A. Ströhle, A. Hahn, and A. Sebastian, “Estimation of the diet-dependent net acid load in 229 worldwide historically studied hunter-gatherer societies,” American Journal of Clinical Nutrition, vol. 91, no. 2, pp. 406–412, 2010.
- A. Sebastian, L. A. Frassetto, D. E. Sellmeyer, R. L. Merriam, and R. C. Morris Jr., “Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors,” American Journal of Clinical Nutrition, vol. 76, no. 6, pp. 1308–1316, 2002.
- L. Frassetto, R. C. Morris, Jr. R.C. Jr., D. E. Sellmeyer, K. Todd, and A. Sebastian, “Diet, evolution and aging—the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet,” European Journal of Nutrition, vol. 40, no. 5, pp. 200–213, 2001.
- M. Konner and S. Boyd Eaton, “Paleolithic nutrition: twenty-five years later,” Nutrition in Clinical Practice, vol. 25, no. 6, pp. 594–602, 2010.
- R. D. Lindeman and R. Goldman, “Anatomic and physiologic age changes in the kidney,” Experimental Gerontology, vol. 21, no. 4-5, pp. 379–406, 1986.
- S. T. Reddy, C. Y. Wang, K. Sakhaee, L. Brinkley, and C. Y. Pak, “Effect of low-carbohydrate high-protein diets on acid-base balance, stone-forming propensity, and calcium metabolism,” American Journal of Kidney Diseases, vol. 40, no. 2, pp. 265–274, 2002.
- Y. S. Malov and A. N. Kulikov, “Bicarbonate deficiency and duodenal ulcer,” Terapevticheskii Arkhiv, vol. 70, no. 2, pp. 28–32, 1998.
- H. Ohman and A. Vahlquist, “In vivo studies concerning a pH gradient in human stratum corneum and upper epidermis,” Acta Dermato-Venereologica, vol. 74, no. 5, pp. 375–379, 1994.
- D. G. Ferris, S. L. Francis, E. D. Dickman, K. Miler-Miles, J. L. Waller, and N. McClendon, “Variability of vaginal pH determination by patients and clinicians,” Journal of the American Board of Family Medicine, vol. 19, no. 4, pp. 368–373, 2006.
- T. Remer and F. Manz, “Estimation of the renal net acid excretion by adults consuming diets containing variable amounts of protein,” American Journal of Clinical Nutrition, vol. 59, no. 6, pp. 1356–1361, 1994.
- T. Remer, “Influence of diet on acid-base balance,” Seminars in Dialysis, vol. 13, no. 4, pp. 221–226, 2000.
- T. R. Fenton, M. Eliasziw, S. C. Tough, A. W. Lyon, J. P. Brown, and D. A. Hanley, “Low urine pH and acid excretion do not predict bone fractures or the loss of bone mineral density: a prospective cohort study,” BMC Musculoskeletal Disorders, vol. 11, article 88, 2010.
- E. Boelsma, L. P. L. van de Vijver, R. A. Goldbohm, I. A. A. Klöpping-Ketelaars, H. F. J. Hendriks, and L. Roza, “Human skin condition and its associations with nutrient concentrations in serum and diet,” American Journal of Clinical Nutrition, vol. 77, no. 2, pp. 348–355, 2003.
- B. A. Ince, E. J. Anderson, and R. M. Neer, “Lowering dietary protein to U.S. recommended dietary allowance levels reduces urinary calcium excretion and bone resorption in young women,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 8, pp. 3801–3807, 2004.
- W. F. Boron, “Regulation of intracellular pH,” Advances in Physiology Education, vol. 28, pp. 160–179, 2004.
- T. Remer and F. Manz, “Potential renal acid load of foods and its influence on urine pH,” Journal of the American Dietetic Association, vol. 95, no. 7, pp. 791–797, 1995.
- T. R. Fenton, M. Eliasziw, A. W. Lyon, S. C. Tough, and D. A. Hanley, “Meta-analysis of the quantity of calcium excretion associated with the net acid excretion of the modern diet under the acid-ash diet hypothesis,” American Journal of Clinical Nutrition, vol. 88, no. 4, pp. 1159–1166, 2008.
- A. Sebastian and R. C. Morris Jr., “Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate,” New England Journal of Medicine, vol. 331, no. 4, p. 279, 1994.
- B. Dawson-Hughes, S. S. Harris, N. J. Palermo, C. Castaneda-Sceppa, H. M. Rasmussen, and G. E. Dallal, “Treatment with potassium bicarbonate lowers calcium excretion and bone resorption in older men and women,” Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 1, pp. 96–102, 2009.
- R. P. Heaney, M. S. Dowell, C. A. Hale, and A. Bendich, “Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D,” Journal of the American College of Nutrition, vol. 22, no. 2, pp. 142–146, 2003.
- G. K. Schwalfenberg, S. J. Genuis, and M. N. Hiltz, “Addressing vitamin D deficiency in Canada: a public health innovation whose time has come,” Public Health, vol. 124, no. 6, pp. 350–359, 2010.
- K. C. Lu, S. H. Lin, F. C. Yu, S. H. Chyr, and S. D. Shieh, “Influence of metabolic acidosis on serum 1,25(OH)2D3 levels in chronic renal failure,” Mineral and Electrolyte Metabolism, vol. 21, no. 6, pp. 398–402, 1995.
- T. R. Fenton, A. W. Lyon, M. Eliasziw, S. C. Tough, and D. A. Hanley, “Phosphate decreases urine calcium and increases calcium balance: a meta-analysis of the osteoporosis acid-ash diet hypothesis,” Nutrition Journal, vol. 8, article 41, 2009.
- S. B. Hulley, J. M. Vogel, C. L. Donaldson, J. H. Bayers, R. J. Friedman, and S. N. Rosen, “The effect of supplemental oral phosphate on the bone mineral changes during prolonged bed rest,” Journal of Clinical Investigation, vol. 50, no. 12, pp. 2506–2518, 1971.
- T. R. Fenton, A. W. Lyon, M. Eliasziw, S. C. Tough, and D. A. Hanley, “Meta-analysis of the effect of the acid-ash hypothesis of osteoporosis on calcium balance,” Journal of Bone and Mineral Research, vol. 24, no. 11, pp. 1835–1840, 2009.
- J. D. Supplee, G. E. Duncan, B. Bruemmer, J. Goldberg, Y. Wen, and J. A. Henderson, “Soda intake and osteoporosis risk in postmenopausal American-Indian women,” Public Health Nutrition, pp. 1–7, 2011.
- T. R. Fenton, S. C. Tough, A. W. Lyon, M. Eliasziw, and D. A. Hanley, “Causal assessment of dietary acid load and bone disease: a systematic review & meta-analysis applying Hill's epidemiologic criteria for causality,” Nutrition Journal, vol. 10, no. 1, article 41, 2011.
- L. A. Frassetto, R. C. Morris Jr., and A. Sebastian, “Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet,” American Journal of Physiology—Renal Physiology, vol. 293, no. 2, pp. F521–F525, 2007.
- P. Frings-Meuthen, J. Buehlmeier, N. Baecker, et al., “High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses,” Journal of Applied Physiology, vol. 111, no. 2, pp. 537–542, 2011.
- F. P. Cappuccio, E. Meilahn, J. M. Zmuda, and J. A. Cauley, “High blood pressure and bone-mineral loss in elderly white women: a prospective study,” Lancet, vol. 354, no. 9183, pp. 971–975, 1999.
- A. Devine, R. A. Criddle, I. M. Dick, D. A. Kerr, and R. L. Prince, “A longitudinal study of the effect of sodium and calcium intakes on regional bone density in postmenopausal women,” American Journal of Clinical Nutrition, vol. 62, no. 4, pp. 740–745, 1995.
- R. C. Morris Jr., O. Schmidlin, L. A. Frassetto, and A. Sebastian, “Relationship and interaction between sodium and potassium,” Journal of the American College of Nutrition, vol. 25, no. 3, pp. 262S–270S, 2006.
- U. S. Barzel and L. K. Massey, “Excess dietary protein may can adversely affect bone,” Journal of Nutrition, vol. 128, no. 6, pp. 1051–1053, 1998.
- R. P. Heaney and D. K. Layman, “Amount and type of protein influences bone health,” American Journal of Clinical Nutrition, vol. 87, no. 5, pp. 156S–157S, 2008.
- B. Dawson-Hughes, S. S. Harris, and L. Ceglia, “Alkaline diets favor lean tissue mass in older adults,” American Journal of Clinical Nutrition, vol. 87, no. 3, pp. 662–665, 2008.
- G. Garibotto, R. Russo, A. Sofia et al., “Muscle protein turnover in chronic renal failure patients with metabolic acidosis or normal acid-base balance,” Mineral and Electrolyte Metabolism, vol. 22, no. 1–3, pp. 58–61, 1996.
- G. Caso and P. J. Garlick, “Control of muscle protein kinetics by acid-base balance,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 8, no. 1, pp. 73–76, 2005.
- M. J. Webster, M. N. Webster, R. E. Crawford, and L. B. Gladden, “Effect of sodium bicarbonate ingestion on exhaustive resistance exercise performance,” Medicine and Science in Sports and Exercise, vol. 25, no. 8, pp. 960–965, 1993.
- E. McSherry and R. C. Morris Jr., “Attainment and maintenance of normal stature with alkali therapy in infants and children with classic renal tubular acidosis,” Journal of Clinical Investigation, vol. 61, no. 2, pp. 509–527, 1978.
- L. Frassetto, R. C. Morris Jr., and A. Sebastian, “Potassium bicarbonate reduces urinary nitrogen excretion in postmenopausal women,” Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 1, pp. 254–259, 1997.
- J. A. H. Wass and R. Reddy, “Growth hormone and memory,” Journal of Endocrinology, vol. 207, no. 2, pp. 125–126, 2010.
- L. Frassetto, R. C. Morris Jr., and A. Sebastian, “Long-term persistence of the urine calcium-lowering effect of potassium bicarbonate in postmenopausal women,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 2, pp. 831–834, 2005.
- J. Vormann, M. Worlitschek, T. Goedecke, and B. Silver, “Supplementation with alkaline minerals reduces symptoms in patients with chronic low back pain,” Journal of Trace Elements in Medicine and Biology, vol. 15, no. 2-3, pp. 179–183, 2001.
- I. Zofková and R. L. Kancheva, “The relationship between magnesium and calciotropic hormones,” Magnesium Research, vol. 8, no. 1, pp. 77–84, 1995.
- G. Schwalfenberg, “Improvement of chronic back pain or failed back surgery with vitamin D repletion: a case series,” Journal of the American Board of Family Medicine, vol. 22, no. 1, pp. 69–74, 2009.
- E. Groos, L. Walker, and J. R. Masters, “Intravesical chemotherapy. Studies on the relationship between pH and cytotoxicity,” Cancer, vol. 58, no. 6, pp. 1199–1203, 1986.
- S. R. Smith, P. A. Martin, and R. H. T. Edwards, “Tumour pH and response to chemotherapy: an in vivo 31P magnetic resonance spectroscopy study in non-Hodgkin's lymphoma,” British Journal of Radiology, vol. 64, no. 766, pp. 923–928, 1991.
- N. Raghunand and R. J. Gillies, “pH and chemotherapy,” Novartis Foundation Symposium, vol. 240, pp. 199–211, 2001.
- N. Raghunand, X. He, R. Van Sluis et al., “Enhancement of chemotherapy by manipulation of tumour pH,” British Journal of Cancer, vol. 80, no. 7, pp. 1005–1011, 1999.