Organic Compounds Detected in Deciduous Teeth: A Replication Study from Children with Autism in Two Samples
Table 2
Detection frequency and concentration distributions of SVOC in a deciduous tooth crown of 71 IAN children with ASD.
Analyte (parent)
Mean (ng/g)
Number of teeth
Detections
Concentration (ng/g)
Number
Percent
P25
P50
P75
P90
P95
Max
LC/MS/MS-detected analytes
Acetaminophen
0.98
71
31
44%
<1.4
<1.4
5.1
24.4
52.5
1050
DEET
82.2
71
53
75%
<4.3
13.7
47.5
101
198
3270
TCPy (chlorpyrifos)
0.88
71
9
13%
<1.3
<1.3
<1.3
1.9
8.7
18.5
IMPy (diazinon)
0.96
71
9
13%
<1.0
<1.0
<1.0
0.4
2.8
56.7
MEP (DEP)
268.6
31
31
100%
56.5
138
235
870
1290
1720
MnBP (DnBP, BzBP)
229.0
71
61
86%
11.0
34.0
157
730
1270
3250
MiBP (DiBP)
70.24
71
50
70%
<6.0
19.7
62.7
186
342
790
MBzP (BzBP)
2.39
71
4
6%
<10.0
<10.0
<10.0
<10.0
25.4
74.3
MEHP (DEHP)
47.0
56
20
36%
<10
<10
32.9
214
319
715
Polyunsaturated fatty acids
Mean g/g
Number of teeth
Detections
Concentration (g/g)
LA, C18:2 n6
14.1
71
71
100%
4.42
7.58
17.0
34.3
61.2
92.1
ALA, C18:3 n3
0.70
71
15
21%
<1.0
<1.0
<1.0
1.96
3.60
15.4
ARA, C20:4 n6
2.60
71
60
85%
1.29
1.82
3.49
5.23
8.66
15.0
DHA, C22:6 n3
0.31
71
14
20%
<1.0
<1.0
<1.0
1.52
2.09
2.41
MEP reported after matrix blank subtraction. Recovery range of equilibrated spiked surrogates from the 71 teeth was 8–92% for acetaminophen-d4, 55–222% for MEHP-13C4, and 30–163% for C21:0.
