Rituximab Administration in Third Trimester of Pregnancy Suppresses Neonatal B-Cell Development

Table 1

Summary literature search.

Mother	Herold 2001	Kimby 2004	Friedrichs 2006	Scully M 2006	Ojeda-Uribe 2006	Magloire 2006	Decker 2006	Current study
Condition	B-cell lymphoma	NH-lymphoma	Burkitt lymphoma	Thrombotic Thrombocytopenic Purpura	Autoimmune Haemolytic anaemia	Burkitt lymphoma	B-cell-NH lymphoma	ITP
Rituximab 375 mg/m^2	Weekly 4x	Weekly 4x	Weekly 4x	Weekly 4x	—	—	Biweekly 6x	Weekly 4X
Co medication	CHOP^(1)	—	CHOP	Plasma exchange	Corticosteroids	CHOP	CHOP	Prednisone, IgG
Administration time GA	Week 21	Week -1 to 3	Weeks 16–30	Week 27	Week 10	Week 13 to ?	Weeks 16-28	Week 30 to 34
Rituximab level D0^(2)(ng/mL)	—	—	9750	—	—	—	25000	24000
CD19+ B-cells D0 (1 × 10^9/L)	—	—	0	—	—	—	0	0
Child	—	—	—	—	—	—	—	—
GA (weeks)	35	40	41	30	38	39	33	38
Rituximab level D0 (ng/mL)	—	—	32095	—	—	—	30000	6700
CD19+ B-cells (1 × 10^9/L) < week 1 post partum	—	0,1	0	—	0,66	—	approx 0,05	0,08
CD19+ B-cells (1 × 10^9/L) 1 month	normal	—	—	—	1,98	—	—	0,00
CD19+ B-cells (1 × 10^9/L) 3 months	—	—	—	—	—	—	—	0,21
CD19+ B-cells (1 × 10^9/L) 6 months	—	—	—	—	—	—	—	2
Vaccination titres	—	Normal	Normal	—	—	—	Normal	normal
IgA; IgM; IgG (g/L) 1-2 months	—	—	—	—	0,07; 0,3; 4,5-	—	—	<0,07; 0,05; 6,1
IgA; IgM; IgG (g/L) 3 months	—	—	—	—	—	—	—	<0,07; <0,04; 2,8
IgA; IgM; IgG (g/L) ≥6 months	—	IgG normal	Normal	—	—	—	Normal	0,16; 0,53; 2,2

(1) Cyclophosphamid, doxorubicin, vincristin, prednisolon.
(2) Day of birth.