Lack of Disease Specificity Limits the Usefulness of In Vitro Costimulation in HIV- and HCV-Infected Patients
Figure 2
In vitro costimulation has no effect on
antigen-specific T cell responses in HIV-infected patients. PBMCs of 10 HIV-infected patients were tested in IFN-γ ELISPOT assays for their recall responses to HIV peptide pools 1, 2,
and 3 (as described in Section 2)
in the absence (a) or presence of IL-7/IL-15 (b), IFN-α (c), anti-ICOS (d), or
CD28 (e). For each individual, the mean
spot count of duplicate wells is shown. Horizontal bars indicate the means of all individual responses to the
respective antigens. Symbols in (a) also
apply to (b)–(e).
