About this Journal Submit a Manuscript Table of Contents
Clinical and Developmental Immunology
Volume 2010 (2010), Article ID 170432, 13 pages
http://dx.doi.org/10.1155/2010/170432
Review Article

Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients

1Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
2Department of Pathology, Creighton University School of Medicine, Omaha, NE 68178, USA
3Department of Preventative Medicine, Creighton University School of Medicine, Omaha, NE 68178, USA

Received 8 January 2010; Accepted 13 April 2010

Academic Editor: C. Pauza

Copyright © 2010 Kristen M. Drescher et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [18 citations]

The following is the list of published articles that have cited the current article.

  • Yvette Garbe, Ulrike Klier, and Michael Linnebacher, “Semiallogenic fusions of MSI+ tumor cells and activated B cells induce MSI- specific T cell responses,” Bmc Cancer, vol. 11, 2011. View at Publisher · View at Google Scholar
  • Kimberly D. Siegmund, Paul Marjoram, Simon Tavare, and Darryl Shibata, “High DNA Methylation Pattern Intratumoral Diversity Implies Weak Selection in Many Human Colorectal Cancers,” Plos One, vol. 6, no. 6, 2011. View at Publisher · View at Google Scholar
  • Sarah Popek, and Vassiliki L. Tsikitis, “Epidemiology of Inherited Colon Cancer,” Seminars in Colon and Rectal Surgery, vol. 22, no. 2, pp. 77–81, 2011. View at Publisher · View at Google Scholar
  • Frank A. Sinicrope, and Zhineng Jayson Yang, “Prognostic and predictive impact of DNA mismatch repair in the management o f colorectal cancer,” Future Oncology, vol. 7, no. 3, pp. 467–474, 2011. View at Publisher · View at Google Scholar
  • Yvette Garbe, Claudia Maletzki, and Michael Linnebacher, “An MSI Tumor Specific Frameshift Mutation in a Coding Microsatellite of MSH 3 Encodes for HLA-A0201-Restricted CD8(+) Cytotoxic T Cell Epitopes,” Plos One, vol. 6, no. 11, 2011. View at Publisher · View at Google Scholar
  • Sha-Sha Guan, and Guang-Hai Dai, “Molecular biology and clinical features of hereditary non-polyposis colorectal cancer,” Acta Academiae Medicinae Sinicae, vol. 34, no. 3, pp. 293–297, 2012. View at Publisher · View at Google Scholar
  • D. Schiff, E. M. Lam, J. E. Parisi, C. Giannini, J. H. Uhm, B. M. Keegan, and O. H. Kantarci, “A 21-year-old woman with multiple cancers and a new brain lesion,” Neurology, vol. 78, no. 10, pp. 743–749, 2012. View at Publisher · View at Google Scholar
  • Noel F. C. C. de Miranda, Danny Goudkade, Ekaterina S. Jordanova, Carli M. J. Tops, Frederik J. Hes, Hans F. A. Vasen, Tom van Wezel, and Hans Morreau, “Infiltration of Lynch Colorectal Cancers by Activated Immune Cells Associat es with Early Staging of the Primary Tumor and Absence of Lymph Node Metast ases,” Clinical Cancer Research, vol. 18, no. 5, pp. 1237–1245, 2012. View at Publisher · View at Google Scholar
  • Jinru Shia, Hangjun Wang, Garrett M. Nash, and David S. Klimstra, “Lymph Node Staging in Colorectal Cancer: Revisiting the Benchmark of at Lea st 12 Lymph Nodes in R0 Resection,” Journal of The American College of Surgeons, vol. 214, no. 3, pp. 348–355, 2012. View at Publisher · View at Google Scholar
  • Jeong M. Bae, Nam-Yun Cho, Tae-You Kim, and Gyeong H. Kang, “Clinicopathologic and Molecular Characteristics of Synchronous Colorectal Cancers,” Diseases of the Colon & Rectum, vol. 55, no. 2, pp. 181–190, 2012. View at Publisher · View at Google Scholar
  • Amanda I. Phipps, John D. Potter, Polly A. Newcomb, Daniel D. Buchanan, Karen W. Makar, Andrea N. Burnett-Hartman, Anna E. Coghill, Michael N. Passarelli, John A. Baron, Dennis J. Ahnen, and Aung Ko Win, “BRAF mutation status and survival after colorectal cancer diagnosis according to patient and tumor characteristics,” Cancer Epidemiology Biomarkers and Prevention, vol. 21, no. 10, pp. 1792–1798, 2012. View at Publisher · View at Google Scholar
  • N. F. C. C. de Miranda, F. J. Hes, T. van Wezel, and H. Morreau, “Role of the microenvironment in the tumourigenesis of microsatellite unstable and MUTYH-associated polyposis colorectal cancers,” Mutagenesis, vol. 27, no. 2, pp. 247–253, 2012. View at Publisher · View at Google Scholar
  • Justyna Klusek, Stanislaw Gluszek, and Jolanta Klusek, “Selected mutations with high risk of colorectal cancer,” Przeglad Gastroenterologiczny, vol. 7, no. 1, pp. 1–6, 2012. View at Publisher · View at Google Scholar
  • Matthias Kloor, Laura Staffa, Aysel Ahadova, and Magnus Knebel Doeberitz, “Clinical significance of microsatellite instability in colorectal cancer,” Langenbeck's Archives of Surgery, 2013. View at Publisher · View at Google Scholar
  • Pilar Garre, Lorena Martín, Inmaculada Bando, Alicia Tosar, Patricia Llovet, Julián Sanz, Atocha Romero, Miguel Hoya, Eduardo Díaz-Rubio, and Trinidad Caldés, “Cancer risk and overall survival in mismatch repair proficient hereditary non-polyposis colorectal cancer, Lynch syndrome and sporadic colorectal cancer,” Familial Cancer, 2013. View at Publisher · View at Google Scholar
  • Guillermo Aldave, Eva Pay, Francisco Queipo, Miguel Angel Idoate, and Jorge Guridi, “Metástasis de un adenocarcinoma prostático en tronco cerebral en el contexto de un síndrome de Muir-Torre,” Neurocirugía, vol. 24, no. 2, pp. 78–81, 2013. View at Publisher · View at Google Scholar
  • Paul J Barrow, Tara Clancy, and D Gareth Evans, “Key genetic considerations in the management of suspected hereditary colorectal cancer,” Colorectal Cancer, vol. 2, no. 1, pp. 31–41, 2013. View at Publisher · View at Google Scholar
  • Linghua Wang, and David A. Wheeler, “Genomic Sequencing for Cancer Diagnosis and Therapy,” Annual Review of Medicine, vol. 65, no. 1, pp. 33–48, 2014. View at Publisher · View at Google Scholar