The Immune-Modulatory Role of Apolipoprotein E with Emphasis on Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Figure 1

The synthesis and secretion of apoE are found in spleen, brain, lung, kidney, peripheral nerves, muscular tissue, adrenal, ovary and testis, and so forth. Hepatic parenchymal cells are the principal apoE-producing cells in mammalians, presumably accounting for 60% to 75% of plasma apoE, followed by astrocytes, which are the main apoE-producing cells in the brain, macrophages (MΦs), and nonmyelinating Schwann cells (SCs), and so forth.