Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation

Figure 1

Consequences of signaling via GITR and GITRL in different cell types. Shown are effects on cellular reactions of the indicated immune effector cells and tumor cells as emerged from the multitude of available studies. It should be noted that for some of the depicted effector functions different or even opposite results have been reported in some studies.