Theoretical Modeling Techniques and Their Impact on Tumor Immunology

Figure 1

Steps in knowledge generation in system biology. Knowledge on a given biological phenomenon is generated in a stepwise manner by combining modeling and experimental techniques. A model is built up enabling the researcher to perform in silico experiments in order to predict the behavior of the biological system under given conditions. These predictions have, in turn, to be validated via in vivo or in vitro systems, leading to further refinement of the model and the underlying hypothesis.