Proposed model of apoE-mediated lipid antigen presentation and NKT cell activation [89]. Pathogenic microbial lipids (i.e., lipopolysaccharide, LPS) are delivered to APCs as part of a triglyceride-rich lipoprotein or bound to apoE. The lipid complex binds to the LDLR, is internalized, and while trafficked through the endosomal compartments, is processed and loaded onto CD1d for recognition by NKT cells.
