Review Article
Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions
Table 1
Asessment of clinical trials by tumor/DC fusions-based vaccine.
| | Tumor/DC Fusions | | Patient | Clinical | | Tumor | Tumor Cells | Dendritic Cells | Coadministration | Number | Responses | Ref. |
| Melanoma | Autologous | Allogeneic | | 16 | 1 (CR) | [135] | | | | | | 1 (PR) | [136] | | | | | | 5 (SD) | | | | | | | 9 (PD) | | | Autologous | Autologous | | 17 | 1 (PR) | [137] | | | | | | 1 (SD) | | | | | | | 15 (PD) | | | Autologous | Allogeneic | | 13 | 8 (SD) | [138] | | | | | | 3 (SD) | | | | | | | 2 (N) | | | Autologous | Autologous | rh IL-12 | 4 | 4 (PD) | [23] | | Autologous | Allogeneic | rh IL-2 | 11 | 1 (SD) | [139] | | | | | | 10 (PD) | |
| Glioma | Autologous | Autologous | | 8 | 2 (PR) | [23] | | | | | | 1 (SD) | | | | | | | 5 (PD) | | | Autologous | Autologous | rh IL-12 | 12 | 3 (PR) | [24] | | | | | | 2 (MR) | | | | | | | 4 (SD) | | | | | | | 3 (PD) | |
| Renal cell carcinoma | Autologous | Allogeneic | | 22 | 14 (SD) | [138] | | | | | | 2 (PD) | | | | | | | 3 (OR) | | | | | | | 3 (N) | | | Autologous | Autologous | | 13 | 5 (SD) | [142] | | | | | | 8 (PD) | | | Autologous | Allogeneic | | 20 | 2 (PR) | [143] | | | | | | 8 (SD) | | | | | | | 10 (PD) | | | Allogeneic | Allogeneic | | 8 | 3 (SD) | [144] | | | | | | 5 (PD) | | | Autologous | Allogeneic | | 4 | 1 (SD) | [144] | | | | | | 3 (PD) | | | Autologous | Allogeneic | | 10 | 1 (PR) | [145] | | | | | | 6 (SD) | | | | | | | 3 (PD) | |
| Breast cancer | Autologous | Autologous | | 10 | 2 (PR) | [142] | | | | | | 1 (SD) | | | | | | | 7 (PD) | | | Autologous | Autologous | rh IL-12 | 2 | 1 (SD) | [24] | | | | | | 1 (PD) | |
| Gastric/Colorectal cancer | Autologous | Autologous | rh IL-12 | 3 | 1 (SD) | [24] | | | | | | 2 (PD) | |
| Hepatocellular carcinoma | Autologous | Autologous | | 1 | 1 (PD) | [118] |
| Ovarian cancer | Autologous | Autologous | rh IL-12 | 3 | 2 (SD) | [24] | | | | | | 1 (PD) | |
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CR: complete response; PR: partial response; MR: mixed response; SD: stable disease; PD: progressive disease. OR: objective response; N: not evaluated.
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