Engagement of the Mannose Receptor by Tumoral Mucins Activates an Immune Suppressive Phenotype in Human Tumor-Associated Macrophages

Table 1

Affymetrix Gene Expression analysis of selected C-type lectin receptors in human Tumor-Associated Macrophages (TAMs).

Gene symbol/ other names	Intensity°	Modulation^§ LPS/IFNγ	Modulation^§ IL-10
MRC1/CD206 CLEC13D	562 ± 76	0,1*	1,5*
Dectin-1 CLEC7A	482 ± 63	0,3*	1,4*
MDL-1 CLEC5A	468 ± 94	0,3*	0,7
DCIR CLEC4A	359 ± 37	0,7	1,1
MGL-1/CD301 CLEC10A	258 ± 85	0,9	1,1
DCL-1/CD302 CLEC13A	160 ± 42	0.9	1
ENDO-180/CD280 CLEC13E	111 ± 72	0,8	1
DEC-205/CD205 CLEC13B	77 ± 42	2,9*	0,7
DC-SIGN/CD209 CLEC4L	40 ± 13	0,8	0,9
Langerin/ CD207 CLEC4K	42 ± 11	0,9	0,9
PLA2R CLEC13C	25 ± 6	1	1

° Normalized intensity, ^§Fold over untreated TAM. Results are expressed as median values ± SE of 7 different TAM preparations and are presented as normalized intensity signals: modulation of CLR genes after TAM treatment with LPS/IFNγ or IL-10 for 18 hrs. Results are presented as fold over untreated TAM, *𝑃<.05 versus untreated. Experiment of CLR modulation by cytokines was performed in 4 TAM preparations.