Gene Carriers and Transfection Systems Used in the Recombination of Dendritic Cells for Effective Cancer Immunotherapy

Table 2

Genes used for modification of DCs.

Groups	Genes coding factors	Effects
TAAs	Gp100, MART-1, PSA, CEA, MUC-1, p53, OVA, LAMP	Lastingly expressing tumor antigens to induce the adverse effects of T-cells special response
Cytokines	IL-2, IL-7, IL-12, IL-15, IL-18 [131, 132], IL-21, IL-23, IFN, TNF-𝛼	To enhance the activity of antigen-presenting function of DCs,
Chemokines	CCL21, CCL22, XCL1, CXCL9, CXCL19, CX3CL1	To guide lymphocytes to the lymph nodes
		To have angiostatic activity
Costimulatory and adhesion molecules	CD40L, CD70, 4-1BBL, OX40L RANKL, CD54, CD58, CD80	To enhance APC’s ability to generate antitumor immune responses
		To improve adhesion interaction between DCs and T cells