The Role of Syk/CARD9-Coupled C-Type Lectin Receptors in Immunity to Mycobacterium tuberculosis Infections
Figure 1
Mincle- and Dectin-1-mediated signalling in response to mycobacteria. Upon recognition of their mycobacterial ligands, Dectin-1 and Mincle signal via the Syk/CARD9 pathway for the production of inflammatory cytokines and the induction of Th1 and Th17 responses. There is also evidence that Dectin-1 signalling can cooperate with TLR2 to induce protective immunity.
