Cytokine Production by Peripheral Blood CD4⁺ and CD8⁺ T Cells in Atopic Childhood Asthma

Figure 3

Scatterplot showing relationship between disease duration, total serum IgE, cytokine production, lung function indices, and the severity of asthma (degree of disease: 1-intermittent, 2-mild persistent, 3-moderate persistent, and 4-severe persistent asthma). Correlations were calculated using the Spearman test. (a) Duration of disease correlated highly significantly with severity of asthma (𝑟=0.56; 𝑃<.00003). (b) Positive correlation between total serum IgE and severity of asthma was revealed (𝑟=0.4; 𝑃<.001). (c) A highly negative correlation between severity of asthma and FEV₁ was identified (𝑟=−0.72; 𝑃<.000001). (d) There was a weak positive correlation between severity of asthma and the percentage of CD4⁺/IL10⁺

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