Cytokine Production by Peripheral Blood CD4⁺ and CD8⁺ T Cells in Atopic Childhood Asthma

Table 3

Percentage of CD4⁺ T cells and CD8⁺ T cells producing IL-2, IL-4, IL-10, IL-13, IFN-γ, and TNF-α after in vitro activation with phorbol 12-myristate-13-acetate and ionomycin.

	CD4^+/IL-2^+	CD4^+/IL-4^+	CD4^+/IL-10^+	CD4^+/IL-13^+	CD4^+/IFN-γ ^+	CD4^+/TNF-α ^+
Asthma 𝑛=40	7.78±0.41	9.10±0.34^∗	8.73±0.55	13.1±0.39^∗	7.83±0.43^∗∗	7.73±0.36
Controls 𝑛=18	9.11±0.56	6.17±0.39	9.25±0.69	7.83±0.49	11.67±0.58	7.22±0.42
	CD8^+/IL-2^+	CD8^+/IL-4^+	CD8^+/IL-10^+	CD8^+/IL-13^+	CD8^+/IFN-γ ^+	CD8^+/TNF-α ^+
Asthma 𝑛=40	8.08±0.47	8.80±0.28^$	8.9±0.5	13.00±0.38^∗	7.65±0.48	7.75±0.49
Controls 𝑛=18	8.08±0.47	6.08±0.40	8.67±0.63	7.58±0.53	8.50±0.38	6.83±0.44

𝑃-values from Mann-Whitney U-test
^∗𝑃<.00001,^∗∗𝑃<.0001, ^$𝑃<.00003
Data as shown as mean ± SE.