|
| Author | Journal | Year | Type of malignancy | Number of patients | Positive tumor-associated | Correlation with clinicopathologic features |
| B7-H3 expression | Favorable | Adverse |
|
| Sun et al. [29] | Cancer Immunol Immunother | 2010 | Colorectal cancer | 102 | 87.3% | — | Higher tumor B7-H3 correlated with a more advanced tumor grade |
|
| Zang et al. [27] | Mod Pathol | 2010 | Ovarian carcinoma | 103 | 93% of tumor cells | — | Significant shorter survival time and higher incidence of recurrence for patients with positive B7-H3 tumor vasculature |
| 44% of tumor vasculature | | |
| Parker et al. [46] | Int J Radiat Oncol Biol Phys | 2010 | Recurrent prostate cancer | 148 | 100% | — | Increased risk of biochemical recurrence for patients with moderate and marked B7-H3 staining |
|
| Loos et al. [25] | BMC Cancer | 2009 | Pancreatic cancer | 68 | 88.2% | high tumor B7-H3 expression was associated with significantly better postoperative prognosis | — |
|
| Boorjian et al. [44] | Urology | 2009 | Renal angiomyolipoma/ pulmonary lymphangio-leiomyomatosis | 110/7 | 100% and 2.7% | — | — |
|
| Yamato et al. [47] | Br J Cancer | 2009 | Pancreatic cancer | 59 | 93.2% | — | Strong tumor B7-H3 expression was significantly associated with lymph node metastasis and advanced pathological stage |
|
| Crispen et al. [28] | Clin Cancer Res | 2008 | ccRCC | 743 | 17% of tumor cells | — | Either tumor cell or diffuse tumor vasculature B7-H3 expression was significantly associated with an increased risk of death from ccRCC |
| 95% of tumor vasculature |
| Boorjian et al. [30] | Clin Cancer Res | 2008 | Urothelial cell carcinoma | 318 | 70.7% | — | — |
|
| Greorio et al. [45] | Histopathology | 2008 | Neuroblastoma | 53 | 74% | — | High tumor B7-H3 expression was associated with a worse event-free survival |
|
| Zang et al. [43] | PNAS | 2007 | Prostate cancer | 823 | 93% | — | Patients with strong tumor B7-H3 expression were at significantly increased risk of clinical cancer recurrence and cancer-specific death |
|
| Roth et al. [31] | Cancer Res | 2007 | Prostate cancer | 338 | 100% | — | (1) Increasing levels of tumor B7-H3 intensity correlated with worsening clinicopathologic features, including tumor volume, extraprostatic extension, higher Gleason score, seminal vesicle involvement, surgical margins |
| (2) Marked tumor B7-H3 intensity was significantly associated with cancer progression |
| Sun et al. [24] | Lung Cancer | 2006 | NSCLC | 70 | 37.1% | — | High tumor B7-H3 expression was significantly more common in cases with lymph node metastasis |
|
| Wu et al. [26] | World J Gastroenterol | 2006 | Gastric cancer | 102 | 58.8% | Positive tumor B7-H3 expression was significantly associated with better postoperative survival | — |
|
