Vaccines and Immunotherapeutics for the Treatment of Malignant Disease

Table 1

Examples of common tumor antigens.

Category	Antigen	Associated cancer types
Tumor-specific - viral	HPV: L1, E6, E7	Cervical carcinoma
	HBV: HBsAg	Hepatocellular carcinoma
	SV40: Tag	Malignant pleural mesothelioma
Tumor-specific - self	CDK-4	Melanoma
	𝛽-catenin	Melanoma
	Caspase-8	Head/neck
CT antigen	MAGE-A1	Melanoma, myeloma, bladder, breast, prostate, lung, head/neck, esophageal, sarcoma
	NY-ESO-1	Melanoma, myeloma, bladder, breast, prostate, lung, head/neck, esophageal, sarcoma
Overexpression	MUC1	Breast, ovarian
	MUC13/CA-125	Ovarian
	HER-2/neu	Breast, melanoma, ovarian, gastric, pancreatic
	Mesothelin	Malignant pleural mesothelioma, ovarian, pancreatic
	PSMA	Prostate
	TPD52	Prostate, breast, ovarian
Differentiation	CEA	Colon
	Gp100	Melanoma
	MART-1/Melan-A	Melanoma
	Tyrosinase	Melanoma
	PSA	Prostate
	PAP	Prostate

Abbreviations: HPV, human papilloma virus; HBV, hepatitis B virus; SV40, simian virus 40; L, late gene; E, early gene; HBsAg, hepatitis B surface antigen; Tag, large tumor antigen; CDK, cyclin-dependent kinase; CT, cancer/testis; MAGE, melanoma-associated antigen; NY-ESO, New York esophageal squamous cell carcinoma; MUC, mucin; CA, cancer antigen; HER/neu, human epidermal receptor/neurological; PSMA, prostate-specific membrane antigen; TP, tumor protein; CEA, carcinoembryonic antigen; Gp, glycoprotein; MART/Melan-A, melanoma antigen recognized by T cells/melanoma antigen-A; PSA, prostate specific antigen; PAP, prostatic acid phosphatase.