Development of Type 1 Diabetes Mellitus in Nonobese Diabetic Mice Follows Changes in Thymocyte and Peripheral T Lymphocyte Transcriptional Activity

<table>Hierarchical clustering of thymocytes and peripheral CD3<sup>+</sup> lymphocytes of nonobese diabetic (NOD) mice based on microarray gene expression profiling. Dendrograms and heat maps were obtained using the Cluster-Tree View program within the GeneSpring GX (Agilent) platform. Red = upregulation, green = downregulation, and black = unmodulated (Pearson correlation metrics, 75 percentile). The 2,771 differentially expressed genes were divided in six clusters (clusters 1 to 6) according to their relative expression levels and ontology.</table>

Journal of Immunology Research

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Figure 3: Development of Type 1 Diabetes Mellitus in Nonobese Diabetic Mice Follows Changes in Thymocyte and Peripheral T Lymphocyte Transcriptional Activity 

Figure 3 | Development of Type 1 Diabetes Mellitus in Nonobese Diabetic Mice Follows Changes in Thymocyte and Peripheral T Lymphocyte Transcriptional Activity 