Immune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old Paradigms

Table 1

Studies of tumor-infiltrating immune cells (Tregs) and prognosis in colorectal carcinoma.

Study	n	Immune cells	Findings: correlation with prognosis
Salama et al. [31]	967	CD8+, CD45RO+, and FOXP3+ tumor-infiltrating	Positive correlation for T-regs in tumor, negative in normal mucosa
Correale et al. [32]	57	CD4+, CD8+, and FOXP3+ T-cells in stroma adjacent to neoplastic glands	Positive correlation for T-regs
Sinicrope et al. [35]	160	CD4+, CD8+, CD25+, and FOXP3+ T-cells	Negative correlation for T-regs. Positive correlation for CD3+ T-cells
Frey et al. [33]	1420	FOXP3+ T-cells	Positive correlation for FOXP3+ T-cells
Nosho et al. [34]	768	CD3+, CD8+, CD45RO+, and FOXP3+ T-cells	Positive correlation for CD8+, CD45RO+, and FOXP3+ T-cells.